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BOLD-MRI in ten patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery

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Abstract

Changes of myocardial oxygenation can be studied by measurements of the apparent transverse relaxation timeT *2 , which is correlated with the oxygenation state of hemoglobin. In this study, ten patients with coronary artery disease (CAD) underwent blood oxygenation level dependent (BOLD)T *2 measurements using a segmented gradient echo pulse sequence with ten echoes.T *2 measurements were performed in a single short-axis slice of the heart at rest and under pharmacological stress with dipyridamole (DIP), which increases myocardial blood flow. For comparison, all patients underwent X-ray angiography and stress-echocardiography within 4 days after the MR exam. In one patient, MR examination was repeated 10 weeks after percutaneous transluminal coronary angioplasty (PTA). In the differentialT *2 maps, expected ischemic areas of myocardium were identified in six patients. In these regions,T *2 values (30±8 ms) were significantly reduced when compared to the remaining myocardium (48±9 ms,P<0.01). In four patients, the myocardial region of interest could not be assessed owing to severe susceptibility artifacts in the ischemic region. The success of the PTA treatment could be visualized from a more homogeneous DIP induced increase inT *2 within the ischemic myocardium (from 26±1 to 29±1 ms before PTA versus 26±1 to 31±4 ms after PTA,P<0.001.

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Authors and Affiliations

  1. Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum (DKFZ), 69120, Heidelberg, Germany

    Christian M. Wacker, Andreas W. Hartlep, Gerhard van Kaick & Lothar R. Schad

  2. II. Med. Univ. Klinik Mannheim/Heidelberg, 68135, Mannheim, Germany

    Christian M. Wacker, Wolfgang R. Bauer, Stefan Pfleger & Georg Ertl

  3. Tumorzentrum Heidelberg/Mannheim, 69120, Heidelberg, Germany

    Michael Bock

Authors
  1. Christian M. Wacker
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  2. Michael Bock
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  3. Andreas W. Hartlep
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  4. Wolfgang R. Bauer
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  5. Gerhard van Kaick
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  6. Stefan Pfleger
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  7. Georg Ertl
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  8. Lothar R. Schad
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Correspondence to Lothar R. Schad.

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Wacker, C.M., Bock, M., Hartlep, A.W. et al. BOLD-MRI in ten patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery. MAGMA 8, 48–54 (1999). https://doi.org/10.1007/BF02590635

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  • DOI: https://doi.org/10.1007/BF02590635

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