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Comparative histologic study of adenomas of the large intestine in Japan and England, with special reference to malignant potential

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Diseases of the Colon & Rectum

Summary

The malignant potential of large-intestinal adenomas varies with size, histologic type, and grade of epithelial atypia in the same way in England and in Japan. Adenomas in England have greater malignant potential than those in Japan because they grow larger and more often show a villous growth pattern. Although the adenomacarcinoma sequence operates in the same way in the two countries, it is suggested that the higher incidence of colorectal cancer in England is due to the greater prevalence as well as the greater size of English adenomas. More studies of the epidemiology and geographic pathology of large-intestinal adenomas are needed to clarify their importance as a predisposing cause of colorectal cancer in low-risk as well as high-risk areas.

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References

  1. Arminski TC, McLean DW: Incidence and distribution of adenomatous polyps of the colon and rectum based on 1,000 autopsy examinations. Dis Colon Rectum 7: 249, 1964

    PubMed  CAS  Google Scholar 

  2. Berg JW, Howell MA: The geographic pathology of bowel cancer. Cancer (suppl) 34: 807, 1974

    Google Scholar 

  3. Burkitt DP, Walker AR, Painter NS: Effect of dietary fibre on stools and transit-times, and its role in the causation of disease. Lancet 2: 1408, 1972

    Article  PubMed  CAS  Google Scholar 

  4. Correa P, Duque E, Cuello C, et al: Polyps of the colon and rectum in Cali, Colombia, Int J Cancer 9: 86, 1972

    Article  PubMed  CAS  Google Scholar 

  5. Histological Typing of Intestinal Tumours (1976). International Histological Classification of Tumours, World Health Organization (in press)

  6. Morson BC, Bussey HJ: Predisposing causes of intestinal cancer. Curr Probl Surg (Feb) 1970 pp 1–50

    Article  Google Scholar 

  7. Morson BC, Dawson IM: Gastrointestinal Pathology, Oxford, Blackwell Scientific Publications, 1972, 676 pp

    Google Scholar 

  8. Muto T, Bussey HJ, Morson BC: The evolution of cancer of the colon and rectum. Cancer, 36: 2251–2270, 1975

    PubMed  CAS  Google Scholar 

  9. Potet F, Soullard J: Polyps of the rectum and colon. Gut 12: 468, 1971

    PubMed  CAS  Google Scholar 

  10. Sato E: Adenomatous polyps of large intestine in autopsy and surgical material. Gann 65: 295, 1974

    PubMed  CAS  Google Scholar 

  11. Segi M, Kurihara M: Cancer Mortality for selected sites in 24 countries. No. 6 (1966–1967). Tokyo, Japan Cancer Society, 1972

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Univesity of Tokyo, Tokyo, Japan

    T. Muto M.D. & K. Ishikawa M.D.

  2. Department of Pathology, University of Tokyo, Tokyo, Japan

    I. Kino M.D.

  3. Department of Pathology, Cancer Institute, Tokyo, Japan

    K. Nakamura M.D. & H. Sugano M.D.

  4. The Pathology Department of St. Mark's Hospital, City Road, EC1V 2PS, London, England

    T. Muto M.D., K. Ishikawa M.D., I. Kino M.D., K. Nakamura M.D., H. Sugano M.D., H. J. R. Bussey Ph.D. & B. C. Morson M.D.

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  1. T. Muto M.D.
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  2. K. Ishikawa M.D.
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  3. I. Kino M.D.
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  4. K. Nakamura M.D.
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  5. H. Sugano M.D.
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  6. H. J. R. Bussey Ph.D.
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  7. B. C. Morson M.D.
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Muto, T., Ishikawa, K., Kino, I. et al. Comparative histologic study of adenomas of the large intestine in Japan and England, with special reference to malignant potential. Dis Colon Rectum 20, 11–16 (1977). https://doi.org/10.1007/BF02587445

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  • DOI: https://doi.org/10.1007/BF02587445

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