Skip to main content

Advertisement

SpringerLink
Log in

A trial of 5-fluorouracil andCorynebacterium parvum in advanced colorectal carcinoma

  • Published:
Diseases of the Colon & Rectum

Summary

This study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum IgM. Serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, T-lymphocyte counts, B-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treatment with either chemotherapy alone or chemoimmunotherapy. In 33 patients chosen at random to receive either 5-FU alone or 5-FU in combination with intramuscularly administeredC. parvum, there was no evidence of objective response or influence on survival. Intramuscularly administeredC. parvum, in the dose and schedule used, produced no evident immunologic or therapeutic effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abdallah AM, Soukop M, Bell G, et al: A controlled study of 5-fluorouracilversus 5-fluorouracil and Methyl-CCNU in advanced gastrointestinal adenocarcinoma. Clin Oncol 3: 247, 1977

    PubMed  CAS  Google Scholar 

  2. Aisenberg AC: An introduction to immunosuppressants. Adv Pharmacol Chemother 8: 31, 1970

    Article  PubMed  CAS  Google Scholar 

  3. Anthony HM, Kirk JA, Madsen KE, et al: E and EAC rosetting lymphocytes in patients with carcinoma of bronchus. I. Some parameters of the test and its prognostic significance. Clin Exp Immunol 20: 29, 1975

    PubMed  CAS  Google Scholar 

  4. Baker LH, Talley RW, Matter R, et al: Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU: A southwest oncology group study. Cancer 38: 1, 1976

    Article  PubMed  CAS  Google Scholar 

  5. Bolton PM, Mander AM, Davidson JM, et al: Cellular immunity in cancer: Comparison of delayed hypersensitivity skin tests in three common cancers. Br Med J 3: 18, 1975

    PubMed  CAS  Google Scholar 

  6. Carter SK, Friedman M: Integration of chemotherapy into combined modality treatment of solid tumors. II. Large bowel carcinoma. Cancer Treat Rev 1: 111, 1974

    Article  Google Scholar 

  7. Currie GA, Bagshawe KD: Active immunotherapy withCorynebacterium parvum and chemotherapy in murine fibrosarcomas. Br Med J 1: 541, 1970

    Article  PubMed  CAS  Google Scholar 

  8. Dimitrov N, Andre F: Applications in experimental and clinical oncology.In:Corynebacterium parvum. New York, Plenum Publishing Corporation, 1975, vol. 1, p 173

    Google Scholar 

  9. Fisher B, Wolmark N, Rubin H, et al: Further observations on the inhibition of tumor growth byCorynebacterium parvum with cylophosphamide. I. Variation in administration of both agents. J Natl Cancer Inst 55: 1147, 1975

    PubMed  CAS  Google Scholar 

  10. Halpern BN, Biozzi G, Stiffel C, et al: Inhibition of tumor growth by administration of killedCorynebacterium parvum. Nature 212: 853, 1966

    Article  PubMed  CAS  Google Scholar 

  11. Israel I: Immunochemotherapy withCorynebacterium parvum in disseminated cancer. Ann NY Acad Sci 277: 241, 1976

    Article  PubMed  CAS  Google Scholar 

  12. Israel L, Edelstein R: Immunological control of cancer (letter). Lancet 1: 979, 1975

    Article  PubMed  CAS  Google Scholar 

  13. Jacobs EM, Luce JK, Wood DA: Treatment of cancer with weekly intravenous 5-fluorouracil. Cancer 22: 1233, 1968

    Article  PubMed  CAS  Google Scholar 

  14. James K, Clunie GJ, Woodruff MF, et al: The effect ofCorynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients. Br J Cancer 32: 310, 1975

    PubMed  CAS  Google Scholar 

  15. Kaplan ME, Clark C: An improved rosetting assay for detection of human T-lymphocytes. J Immunol Methods 5: 131, 1974

    Article  PubMed  CAS  Google Scholar 

  16. Keller R: Abrogation of antitumor effects ofCorynebacterium parvum and BCG by antimacrophage agents: Brief communication. J Natl Cancer Inst 59: 1751, 1977

    PubMed  CAS  Google Scholar 

  17. Kim US, Papatestas AE: Peripheral lymphocyte counts in colonic disease (letter). Lancet 2: 462, 1974

    Article  PubMed  CAS  Google Scholar 

  18. Lee YN, Sparks FC, Eilber FR, et al: Delayed cutaneous hypersensitivity and peripheral lymphocyte counts in patients with advanced cancer. Cancer 35: 748, 1975

    Article  PubMed  CAS  Google Scholar 

  19. Lokich JJ, Skarin AT, Mayer RJ, et al: Lack of effectiveness of combined 5-fluorouracil and methyl-CCNU therapy in advanced colorectal cancer. Cancer 40: 2792, 1977

    Article  PubMed  CAS  Google Scholar 

  20. Mancini G, Carbonara AO, Heremans JF: Immunochemical quantitation of antigens by single radial immunodiffusion. Int J Immunochem 2: 235, 1965

    CAS  Google Scholar 

  21. Moertel CG: Clinical management of advanced gastrointestinal cancer. Cancer 36: 675, 1975

    Article  PubMed  CAS  Google Scholar 

  22. Moertel CG: Gastrointestinal cancer: Treatment with fluorouracil-nitrosourea combinations. JAMA 235: 2135, 1976

    Article  PubMed  CAS  Google Scholar 

  23. Moertel CG: Reitemeier RJ: Advanced Gastrointestinal Cancer/Clinical Management and Chemotherapy. New York, Harper and Row, 1969, p 3

    Google Scholar 

  24. Rao B, Wanebo HJ, Ochoa M Jr, et al: IntravenousCorynebacterium parvum: An adjunct to chemotherapy for resistant advanced ovarian cancer. Cancer 39: 514, 1977

    Article  PubMed  CAS  Google Scholar 

  25. Scott MT:Corynebacterium parvum as an immunotherapeutic anticancer agent. Semin Oncol 1: 367, 1974

    PubMed  CAS  Google Scholar 

  26. Woodruff MF, Boak JL: Inhibitory effect of injection ofCorynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer 20: 345, 1966

    PubMed  CAS  Google Scholar 

  27. Woodruff MF, Clunie GJ, McBride WH, et al: The effect of intravenous and intramuscular injection ofCorynebacterium parvum.In Corynebacterium parvum. New York, Plenum Publishing Corporation, 1975, p 383

    Google Scholar 

  28. Woodruff MF, McBride WH, Dunbar N: Tumor growth, phagocytic activity and antibody response inCorynebacterium parvum-treated mice. Clin Exp Immunol 17: 509, 1974

    PubMed  CAS  Google Scholar 

  29. Zacharski LR, Linman JW: Lymphocytopenia: Its causes and significance. Mayo Clin Proc 46: 168, 1971

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Queensland, Clinical Sciences Building, Royal Brisbane Hospital, 4029, Brisbane, Australia

    I. R. Gough M.B, B.S., F.R.A.C.S., G. J. A. Clunie M.B., Ch.M., F.R.A.C.S., P. M. Bolton M.B., D.S., F.R.A.C.S., M. Dury B.Sc. & W. Burnett M.B., Ch.M., F.R.A.C.S

Authors
  1. I. R. Gough M.B, B.S., F.R.A.C.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. J. A. Clunie M.B., Ch.M., F.R.A.C.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. M. Bolton M.B., D.S., F.R.A.C.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Dury B.Sc.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. Burnett M.B., Ch.M., F.R.A.C.S
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Gough, I.R., Clunie, G.J.A., Bolton, P.M. et al. A trial of 5-fluorouracil andCorynebacterium parvum in advanced colorectal carcinoma. Dis Colon Rectum 22, 223–227 (1979). https://doi.org/10.1007/BF02586879

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02586879

Keywords

Search

Navigation