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Dietary-induced thermogenesis in obesity. Response to mixed and carbohydrate meals

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The possibility that dietary-induced thermogenesis may be decreased in obesity has been proposed in recent years. However, the results of human studies so far obtained are conflicting. The present research was undertaken in order to clarify this question. We studied postprandial thermogenesis induced by ingestion of a mixed meal and of a carbohydrate mixture in 15 normal and 12 obese subjects. Blood glucose and plasma insulin levels were measured at the same time. The data obtained have shown that the mean resting metabolic rate (RMR) expressed as a function of body weight3/4, is almost the same in obese as in normal-weight subjects (0.115±0.018vs 0.133±0.021 kj/min/kg3/4, respectively). Moreover, the increment of mixed-meal induced thermogenesis (MM-IT) was 48±22% in normal and −0.8±12% in obese subjects, respectively (p<0.01). Carbohydrate induced thermogenesis (CHO-IT) appeared slightly higher in normal-weight than in obese subjects (159±66vs 98±46). After carbohydrate ingestion we observed a higher glycemic and insulinemic response in obesity. These results indicate that thermogenesis induced by ingestion of food is reduced in obese subjects; they are also compatible with the idea that insulin resistance could play a role in this phenomenon.

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References

  1. Bessard T., Schutz Y., Jéquier E.: Energy expenditure and postprandial thermogenesis in obese women before and after weight loss — Amer. J. clin. Nutr.38, 680–693, 1983.

    PubMed  CAS  Google Scholar 

  2. Contaldo F., Reed L. A., Laviano A., Coltorti A., Pacioni D., Borrelli R., Mancini M.: Postprandial thermogenesis and meal lipid composition in human obesity — Europ. J. clin. Invest.14, 2, 1984.

    Google Scholar 

  3. Felig P., Cunningham J., Levitt M., Hendler R., Nadel E.: Energy expenditure in obesity in fasting and postprandial state — Amer. J. Physiol.244, E45-E51, 1983.

    PubMed  CAS  Google Scholar 

  4. Golay A., Schutz J., Meyer H. U., Thiébaud D., Curchod B., Maeder E., Felber J. P., Jéquier E.: Glucose induced thermogenesis in nondiabetic and diabetic obese subjects — Diabetes31, 1023–1028, 1982.

    PubMed  CAS  Google Scholar 

  5. Jéquier E.: Métabolisme energétique. — Encyclopédie Médico Chirurgicale, Nutrition 10371, A 10, 11, 1980; p. 1.

  6. Jéquier E., Schutz Y.: New evidence for thermogenic defect in human obesity — Int. J. Obesity9 (Suppl. 2), 1–7, 1985.

    Google Scholar 

  7. Jung R. T., Shetty P. S., James W. P. T., Barrand M., Callingham B. A.: Reduced thermogenesis in obesity — Nature (Lond.)279, 322–323, 1979.

    Article  CAS  Google Scholar 

  8. Kaplan M. L., Leveille G. A.: Calorigenic response in obese and nonobese women — Amer. J. clin. Nutr.29, 1108–1113, 1976.

    PubMed  CAS  Google Scholar 

  9. Kleiber M.: The fire of life. Huntington, New York, 1975; p. 180–181.

    Google Scholar 

  10. Nair K. S., Halliday D., Garrow J. S.: Thermic response to isoenergetic protein, carbohydrate or fat meals in lean and obese subjects — Clin. Sci.65, 307–312, 1983.

    PubMed  CAS  Google Scholar 

  11. Ravussin E., Burnard B., Schutz Y., Jéquier E.: Twenty-four hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects — Amer. J. clin. Nutr.35, 366–373, 1982.

    Google Scholar 

  12. Rothwell N. J., Stock M. J.: Regulation of energy balance — Ann. Rev. Nutr.1, 235–256, 1981.

    Article  CAS  Google Scholar 

  13. Schutz Y., Golay A., Felber J.-P., Jéquier E.: Decreased glucose-induced thermogenesis after weight loss in obese subjects: a predisposing factor for relapse of obesity — Amer. J. clin. Nutr.39, 380–387, 1984.

    PubMed  CAS  Google Scholar 

  14. Sharief N. N., Macdonald I.: Differences in dietary-induced thermogenesis with various carbohydrates in normal and overweight men — Amer. J. Nutr.35, 267–272, 1982.

    CAS  Google Scholar 

  15. Shetty P. S., Jung R. T., James W. P. T., Barrand M. A., Callingham B. A.: Postprandial thermogenesis in obesity — Clin. Sci.60, 519–525, 1981.

    PubMed  CAS  Google Scholar 

  16. Wang C. C., Strouse S.: Studies on the metabolism of obesity. III. The specific dynamic action of food — Arch. intern. Med.34, 573–583, 1924.

    CAS  Google Scholar 

  17. Welle S. L., Campbell R. G.: Normal thermic effect of glucose in obese women — Amer. J. clin. Nutr.37, 87–92, 1983.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto di Semeiotica Medica, Patologia Medica III, Università degli Studi di Padova, Padova, Italy

    Carlo De Palo, Cinzia Macor, Nicola Sicolo, Roberto Vettor, Cesare Scandellari & Giovanni Federspil

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  1. Carlo De Palo
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  2. Cinzia Macor
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  3. Nicola Sicolo
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  4. Roberto Vettor
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  5. Cesare Scandellari
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  6. Giovanni Federspil
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De Palo, C., Macor, C., Sicolo, N. et al. Dietary-induced thermogenesis in obesity. Response to mixed and carbohydrate meals. Acta diabet. lat 26, 155–162 (1989). https://doi.org/10.1007/BF02581367

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  • DOI: https://doi.org/10.1007/BF02581367

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