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Role of hepatitis B virus infection in chronic liver disease of diabetic patients: A case-control study

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Summary

In the literature there is no agreement on the prevalence of chronic liver disease (CLD) and the role of hepatitis B virus (HBV) infection in diabetics. We undertook an epidemiological case-control study of the prevalence of CLD and HBV infection in 394 diabetics and 265 healthy subjects from Seriate and Como. The results did not show any significant differences between: 1) the prevalence of CLD in the diabetic population and in controls (4.8%vs 4.5%); 2) the prevalence of HBV infection in diabetics (HBsAg+: 8.3%: HBVAb+: 55.8%) and in controls (HBsAg+: 8.6%; HBVAb+: 54.7%); 3) the prevalence of HBV infection in diabetics with CLD (HBsAg+: 21%; HBVAb+: 52.6%) and in controls with CLD (HBsAg+: 16.6%; HBVAb+: 50%); 4) the prevalence of HBV infection in diabetics with and without CLD (HBsAg+: 21%vs 7.7%; HBVAb+: 52.6%vs 56%); 5) the prevalence of HBV infection in diabetics treated by injection and orally (HBsAg+: 6.9%vs 8.6%; HBVAb+: 58.3%vs 55.2%). The relative risk of CLD for the factor HBsAg+ was 3.2 in the diabetic populationvs 1.4 in controls. In view of the presence of antidelta antibodies (HDVAb) in 25% of HBsAg+ diabetics with CLD and the lack of HBV markers in 26.3% of diabetics with CLD, we assume that other viruses (Delta, nonA-nonB) may play roles. Probably the interaction of all possible etiopathogenetic factors (alcohol, viruses, glycometabolic derangement) is determinant for CLD in diabetics.

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Authors and Affiliations

  1. Divisione di Medicina e Centro Antidiabetico, Ospedale Bolognini, Seriate

    Guido Colloredo Mels & Giovanni Angeli

  2. Medicina A, Ospedale S. Anna, Via Napoleona, 60, 22100, Como, Italy

    Giusi Bettale, Giorgio Bellati, Massimo Guanziroli & Gaetano Idéo

  3. Laboratorio di Analisi, Ospedale Bolognini, Seriate

    Lucio Tiraboschi

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  1. Guido Colloredo Mels
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  2. Giusi Bettale
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  3. Giorgio Bellati
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  4. Massimo Guanziroli
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  5. Lucio Tiraboschi
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  6. Giovanni Angeli
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  7. Gaetano Idéo
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Mels, G.C., Bettale, G., Bellati, G. et al. Role of hepatitis B virus infection in chronic liver disease of diabetic patients: A case-control study. Acta diabet. lat 23, 29–34 (1986). https://doi.org/10.1007/BF02581351

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