Abstract
Balloon-occuluded arterial infusion (BOAI) of bilateral internal iliac arteries produces high drug concentration as well as increased arterial flow of pelvic organs. Twenty-seven patients with primary and locally recurrent gynecologic malignancies were treated with BOAI of cisplatinum. Six of 10 patients with primary advanced uterine cancer and 5 of 11 patients with recurrent cancer showed clinical response. In 6 patients, BOAI was performed as an adjuvant therapy to radiation or other chemotherapy. Toxicity was similar to that seen with systemic treatment using cisplatinum, but its frequency and degree were less severe.
Similar content being viewed by others
References
Smith JP, Randall GE, Castro JR, Lindberg RD (1972) Hypogastric artery infusion and radiation therapy for advanced squamous cell carcinoma of the cervix. Am J Roentgenol Rad Ther Nucl Med 114:110–115
Morrow CP, DiSaia PJ, Mangan CF, Lagasse LD (1977) Continuous pelvic arterial infusion with bleomycin for squamous carcinoma of the cervix recurrent after irradiation therapy. Cancer Treat Rep 61:1403–1405
Swenerton KD, Evers JA, White GW, Boyes DA (1979) Intermittent pelvic infusion with vincristine, bleomycin and mitomycin C for advanced recurrent carcinoma of the cervix. Cancer Treat Rep 63:1379–1381
Carlson JA Jr, Freedman RS, Wallace S, Chuang VP, Wharton JT, Rutledge FN (1981) Intraarterial cis-Platinum in the management of squamous cell carcinoma of the uterine cervix. Gynecol Oncol 12:92–98
Kawagoe K, Iijima S, Tsunoda H, Sasaki J, Inaba J (1983) Intra-arterial infusion of Oncostaticus in recurrent cervical carcinoma. Acta Obstet Gynaecol Jpn 35:787–795 (in Jps).
Cohen CJ, Castro-Marin A, Deppe G, Bruckner HW, Holland JF (1978) Chemotherapy of advanced recurrent cervical cancer with platinum II: Preliminary report. Proc Am Soc Clin Oncol 19:401
Thigpen T, Shingleton H, Homesley H, LaGasse L, Blessing J (1979) cis-Dichlorodiammineplatinum (II) in the treatment of gynecologic malignancies: Phase II trials by the Gynecologic Oncology Group. Cancer Treat Rep 63:1549–1555
Stehman FB, Balloon SC, LaGasse LD (1979) cis-Platinum in advanced gynecologic malignancy. Gynecol Oncol 7:349–360
Thigpen T, Shingleton H, Homesley H, LaGasse L, Blessing J (1981) Cis-Platinum in treatment of advanced or recurrent squamous cell carcinoma of the cervix: A phase II study of the gynecologic oncology group. Cancer 48:899–903
Calvo DB III, Patt YZ, Wallace S, Chuang VP, Benjamin RS, Pritchard JD, Hersh EM, Bodey GP Sr, Mavligit GM (1980) Phase I–II trial of percutaneous intra-arterial cis-dichlorodiammine platinum (II) for regionally confined malignancy. Cancer 45:1278–1283
Sorbe B, Frankendal B (1984) Bleomycin-adriamycin-cisplatin combination chemotherapy in the treatment of primary advanced and recurrent cervical carcinoma. Obstet Gynecol 63:167–170
Sagiyama K, Uozumi J, Aoki K (1983) Efficacy of “tworoute chemotherapy” using intra-arterial cisplatin and ivsodium thiosulfate, its antidote, in rat bladder tumor. Cancer Treat Rep 67:567–572
DiSaia PJ, Rich WM (1981) Advanced and recurrent carcinoma of cervix. In: Coppleson (ed) Gynecologic oncology. Churchill Livingstone. New York, pp 517–527
Hall DJ, Diasio R, Goplerud DR (1981) cis-Platinum in gynecologic cancer. II. Squamous cell carcinoma of the cervix. Am J Obstet Gynecol 141:305–308
Granmayesh M, Libshitz HI (1979) Vascular system. In: Lipshitz HI (ed) Diagnostic roentogenology of radiotherapy change. Williams & Wilkins, Baltimore, pp 175–201
Friedman MA, Ignoffo RJ (1984) Intraarterial use of adriamycin. In: Ogawa M, Muggia FM, Rozencweig M (eds) Adriamycin: its expanding role in cancer treatment. Excerpta Medica. Amsterdam, pp 387–399
Anderson JH, Gianturco C, Wallace S (1981) Experimental transcatheter intraarterial infusion-occlusion chemotherapy. Invest Radiol 16:496–500
Helmer RE III, Morettin LB, Costanzi JJ (1981) Hepatic artery occlusion with perfusion in the treatment of carcinoid syndrome. Oncology 38:361–364
Kawabata M, Takashima S, Mitsuzane K, Tanaka M, Maeda C, Hamachi J, Nomura S, Matsuoka T, Kobayashi N, Sato M, Nakatsuka H, Yamada R (1984) Balloon-occluded arterial infusion therapy for malignant hepatic tumors. Jpn J Cancer Chemother 11:806–813
Rosenberg B (1977) On the mechanism of action of platinum complexes as anti-cancer agents. J Clin Hematol Oncol 7:17–27
Hall DJ, Diasio R, Goplerud DR (1981) cis-Platinum in gynecologic cancer. III. Toxicity. Am J Obstet Gynecol 141:309–312
Von Hoff DD, Schilsky R, Reichard CM, Reddick RL, Rosenchurig M, Young RC, Muggia FM (1979) Toxic effects of cis-dichlorodiammine platinum (II) in man. Cancer Treat Rep 63:1527–1531
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamashita, Y., Takahashi, M., Bussaka, H. et al. Balloon-occluded arterial infusion therapy in the treatment of primary and recurrent gynecologic malignancies. Cardiovasc Intervent Radiol 12, 188–195 (1989). https://doi.org/10.1007/BF02577151
Issue Date:
DOI: https://doi.org/10.1007/BF02577151