Abstract
Intraarterial administration of chemotherapeutic agents provides greater local concentration at the tumor site without increased systemic toxicity. Although intravenous infusion of cisplatin is known to cause peripheral neuropathy and intraarterial administration has been reported to cause lumbosacral plexopathy, brachial plexopathy has not been described. We present a case in which infusion of cisplatin into the axillary-artery resulted in permanent neurological damage to the posterior cord of the brachial plexus. Proper positioning of the infusion catheter is necessary to minimize potential neural damage.
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Wallace S, Charnsangavej C, Carrasco CH, Bechtel W (1984) Infusion-embolization. Cancer 54:2751–2765
Chuang VP, Wallace S (1981) Arterial infusion and occlusion in cancer patients. Sem Roentgen 16:13–25
Chen H-S, Gross JF (1980) Intra-arterial infusion of anticancer drugs: Theoretic aspects of drug delivery and review of responses. Cancer Treat Rep 64:31–40
Roelofs RI, Hrushesky W, Rogin J, Rosenberg L (1984) Peripheral sensory neuropathy and cisplatin chemotherapy. Neurology 34:934–938
Jaffe N, Bowman R, Wang Y-M, Cangir A, Ayala A, Chuang VP, Wallace S, Murray J (1984) Chemotherapy for primary osteosarcoma by intra-arterial infusion: Review of the literature and comparison with results achieved by the intravenous route. Cancer Bull 36:37–42
Thompson SW, Davis LE, Kornfeld M, Hilgers RD, Standefer JC (1984) Clinical neuropathy: Clinical, electrophysical, morphologic, and toxicologic studies. Cancer 54:1269–1275
Castellanos AM, Glass JP, Yung WKA (1987) Regional nerve injury after intraarterial chemotherapy. Neurology 37:834–837
Pettigrew LC, Glass JP, Maor M, Zornoza J (1984) Diagnosis and treatment of lumbosacral plexopathies in patients with cancer. Arch Neurol 41:1282–1285
Quinn SF, Frau DM, Saff GN, Kavanagh J, Roberts W, Cavanagh D, Clark RA (1988) Neurologic complications of pelvic intraarterial chemoembolization performed with collagen material and cisplatin. Radiology 167:55–57
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Kahn, C.E., Messersmith, R.N. & Samuels, B.L. Technical note: Brachial plexopathy as a complication of intraarterial cisplatin chemotherapy. Cardiovasc Intervent Radiol 12, 47–49 (1989). https://doi.org/10.1007/BF02577128
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DOI: https://doi.org/10.1007/BF02577128