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Lipid peroxidation in experimental spinal cord injury

Comparison of treatment withGinkgo biloba, TRH and methylprednisolone

  • Original Papers
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Research in Experimental Medicine

Abstract

Ischaemia-induced lipid peroxidation is one of the most important factors producing tissue damage in spinal cord injury. In our study, the protective effects ofGinkgo biloba, thyroid releasing hormone (TRH) and methylprednisolone (MP) on compression injury of the rat spinal cord were investigated. For this study 45 rats in four groups, including control, MP, TRH andGingko biloba, were used to determine the formation of malondialdehyde (MDA). All the animals were made paraplegic by the application clip method of Rivlin and Tator. Rats were divided randomly and blindly to one of four treatment groups (ten animals in each). MP andGinkgo biloba treatments significantly decreased MDA levels (F=54.138,P<0.01). These results suggest that MP andGinkgo biloba may have a protective effect against ischaemic spinal cord injury by the antioxidant effect.

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Authors and Affiliations

  1. Department of Neurosurgery, Erciyes University, School of Medicine, TR-38039, Kayseri, Turkey

    R. K. Koç, H. Akdemir, A. Kurtsoy, İ. Kavuncu & A. Paşaoĝlu

  2. Department of Biochemistry, Erciyes University, School of Medicine, TR-38039, Kayseri, Turkey

    H. Paşaoĝlu & İ. Karaküçük

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  1. R. K. Koç
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  2. H. Akdemir
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  3. A. Kurtsoy
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  4. H. Paşaoĝlu
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  5. İ. Kavuncu
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  6. A. Paşaoĝlu
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  7. İ. Karaküçük
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Koç, R.K., Akdemir, H., Kurtsoy, A. et al. Lipid peroxidation in experimental spinal cord injury. Res. Exp. Med. 195, 117–123 (1995). https://doi.org/10.1007/BF02576781

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  • DOI: https://doi.org/10.1007/BF02576781

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