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Treatment of acute spinal cord injuries: comparison of thyrotropin-releasing hormone and nimodipine

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Research in Experimental Medicine

Summary

The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3ml) i.v. 1h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3ml) i.v. 1h after injury followed by 1 mg/kg per hour for 4h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P<0.01).

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Authors and Affiliations

  1. Departments of Neurosurgery, Neurology and Histology, KTÜ Medical Faculty, TR-61080, Trabzon, Turkey

    S. Ceylan, K. Ilbay, S. Baykal, S. Ceylan, U. Şener, M. Özmenoĝlu, M. Kalelioĝlu, F. Aktürk, S. Ş Komsuoĝlu & A. Özoran

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  1. S. Ceylan
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  2. K. Ilbay
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  3. S. Baykal
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  4. S. Ceylan
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  5. U. Şener
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  6. M. Özmenoĝlu
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  7. M. Kalelioĝlu
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  8. F. Aktürk
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  9. S. Ş Komsuoĝlu
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  10. A. Özoran
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Ceylan, S., Ilbay, K., Baykal, S. et al. Treatment of acute spinal cord injuries: comparison of thyrotropin-releasing hormone and nimodipine. Res. Exp. Med. 192, 23–33 (1992). https://doi.org/10.1007/BF02576254

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  • DOI: https://doi.org/10.1007/BF02576254

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