Summary
Pancreatic cancer develops at approximately 25 weeks after 6 weeks of weekly subcutaneous administration of N-nitrosobis (2-oxypropyl)amine in the Syrian golden hamster. We studied the glucose tolerance and insulin secretion during the development of pancreatic cancer in this model. Every 6th week after start of treatment, glucose was infused intravenously for 30 min (10 mg/min). It was found that the glucose tolerance and glucose-stimulated insulin secretion were normal at 6, 12, and 18 weeks after start of treatment compared with agematched saline-injected controls. By contrast, after 24, 30, and 42 weeks an exaggerated plasma-glucose response and a concomitant impaired plasma-insulin response occurred during the glucose infusion (P<0.05). We therefore conclude that the development of pancreatic cancer in this model is accompanied by glucose intolerance and impaired insulin secretion, and that these effects occur concomitantly with the development of cancer.
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References
Ar'Rajab A, Ahreń B (1992) Long term diabetogenic effect of streptozotocin in rats. Pancreas (in press)
Berhowitz D, Greenberg L, Glassman S (1963) The intravenous tolbutamide test as a diagnostic aid in carcinoma of the pancreas. Am J Med Sci 243:150–154, 228–232
Braznin B, Steinberg JP, Leitner W, Sussman KE (1985) The nature of insulin secretory defect in aging rats. Diabetes 34:1168–1173
Bruss ML, Black AL (1978) Enzymatic microdetermination of glycogen. Anal Biochem 84:309–312
Cersosimo E, Pister PWT, Pesola G, McDermott K, Bajoninas D, Brennan MF (1991) Insulin secretion and action in patients with pancreatic cancer. Cancer 67:487–493
Clark CG, Mitchell PEG (1961) Diabetes mellitus and primary carcinoma of the pancreas. BMJ 2:1259–1262
Dawishiba S, Pour PM, Stenram U, Sundler F, Andrèn-Sandberg Å (1992) Immunohistochemical characterization of endocrine cells in experimental exocrine pancreatic cancer in the Syrian golden hamster. Int J Pancreatol (in press)
Eizirik DL, Sandler S (1989) Function and metabolism of pancreatic β-cells maintained in culture following experimentally induced damage. Pharmacol Toxicol 65:163–168
Herbert V, Lau KS, Gottlieb CW, Bleicher SJ (1965) Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 26:1375–1384
Murphy R, Smith FH (1963) Abnormal carbohydrate metabolism in pancreatic carcinoma. Med Clin North Am 47:397–405
Permert J, Mogahi M, Andrén-Sandberg Å, Kazahoff K, Pour PM (1992) Pancreatic mixed ductal-islet tumors. Is this an entitiy? Int J Pancreatol 11:23–29
Pour PM, Wilson RB (1990) Experimental tumors of the pancreas. In: Moosa AR (ed) Tumours of the pancreas. Williams & Wilkins, Baltimore London pp 37–158
Pour PM, Kruger FW, Althoff J, Cardesa A, Mohr U (1974) Cancer of the pancreas induced in the Syrian golden hamster. Am J Pathol 76:349–358
Schwartz SS, Zeidler A, Moossa AR, Kuku SF, Rubenstein A (1978) A prospective study of glucose tolerance, insulin, C-peptide and glucagon responses in patients with pancreatic carcinoma. Dig Dis Sci 23:1107–1114
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Ahrén, B., Andrén-Sandberg, Å. Glucose tolerance and insulin secretion in experimental pancreatic cancer in the Syrian hamster. Res. Exp. Med. 193, 21–26 (1993). https://doi.org/10.1007/BF02576207
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DOI: https://doi.org/10.1007/BF02576207