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Dietary fatty acids and the immune system

  • Lipids And Immunity
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Lipids

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Abbreviations

IL:

interleukin

NK:

natural killer

PUFA:

polyunsaturated fatty acid

TNF:

tumor necrosis factor

References

  1. Mertin, J., and Meade, C.J. (1977) Relevance of Fatty Acids to Multiple Sclerosis,Br. Med. Bull. 33, 67–71.

    PubMed  CAS  Google Scholar 

  2. Calder, P.C. (1998) Dietary Fatty Acids and Lymphocyte Functions,Proc. Nutr. Soc. 57, 487–502.

    Article  PubMed  CAS  Google Scholar 

  3. Mertin, J. (1976) Effect of Polyunsaturated Fatty Acids (PUFA) on Skin Allograft Survival and Primary and Secondary Cytotoxic Response in Mice,Transplantation 21, 1–4.

    Article  PubMed  CAS  Google Scholar 

  4. Kromann, N., and Green, A. (1980) Epidemiological Studies in the Upernavik District, Greenland,Acta Med. Scand. 208, 401–406.

    Article  PubMed  CAS  Google Scholar 

  5. Calder, P.C. (1996) Immunomodulatory and Anti-inflammatory Effects of n-3 Polyunsaturated Fatty Acids,Proc. Nutr. Soc. 55, 737–774.

    Article  PubMed  CAS  Google Scholar 

  6. Calder, P.C. (1997) n-3 Polyunsaturated Fatty Acids and Cytokine Production in Health and Disease,Ann. Nutr. Metab. 41, 203–234.

    PubMed  CAS  Google Scholar 

  7. Calder, P.C. (1998) Dietary Fatty Acids and the Immune System,Nutr. Rev. 56, S70-S83.

    Article  PubMed  CAS  Google Scholar 

  8. Alexander, N.J., and Smythe, N.L. (1988) Dietary Modulation ofin vitro Lymphocyte Function,Ann. Nutr. Metab. 32, 192–199.

    PubMed  CAS  Google Scholar 

  9. Kelley, D.S., Nelson, G.J., Serrato, C.M., Schmidt, P.C., and Branch, L.B. (1988) Effects of Type of Dietary Fat on Indices of Immune Status of Rabbits,J. Nutr. 118, 1376–1384.

    PubMed  CAS  Google Scholar 

  10. Fritsche, K.L., Cassity, N.A., and Huang, S.-C. (1991) Effect of Dietary Fat Source on Antibody Production and Lymphocyte Proliferation in Chickens,Poultry Sci. 70, 611–617.

    CAS  Google Scholar 

  11. Yaqoob, P., Newsholme, E.A., and Calder, P.C. (1994) The Effect of Dietary Lipid Manipulation on Rat Lymphocyte Subsets and Proliferation,Immunology 82, 603–610.

    PubMed  CAS  Google Scholar 

  12. Sanderson, P., Yaqoob, P., and Calder, P.C. (1995) Effects of Dietary Lipid Manipulation upon Rat Spleen Lymphocyte Functions and the Expression of Lymphocyte Surface Molecules,J. Nutr. Environ. Med. 5, 119–132.

    CAS  Google Scholar 

  13. Yaqoob, P., and Calder, P.C. (1995) The Effects of Dietary Lipid Manipulation on the Production of Murine T-Cell-Derived Cytokines,Cytokine 7, 548–553.

    Article  PubMed  CAS  Google Scholar 

  14. Jolly, C.A., Jiang, Y.-H., Chapkin, R.S., and McMurray, D.N. (1997) Dietary (n-3) Polyunsaturated Fatty Acids Suppress Murine Lymphoproliferation, Interleukin-2 Secretion and the Formation of Diacylglycerol and Ceramide,J. Nutr. 127, 37–43.

    PubMed  CAS  Google Scholar 

  15. Meydani, S.N., Yogeeswaran, G., Liu, S., Baskar, S., and Meydani, M. (1988) Fish Oil and Tocopherol-Induced Changes in Natural Killer Cell-Mediated Cytotoxicity and PGE2 Synthesis in Young and Old Mice,J. Nutr. 118, 1245–1252.

    PubMed  CAS  Google Scholar 

  16. Berger, A., German, J.B., Chiang, B.L., Ansari, A.A., Keen, C.L., Fletcher, M.P., and Gershwin, M.R. (1993) Influence of Feeding Unsaturated Fats on Growth and Immune Status of Mice,J. Nutr. 123, 225–233.

    PubMed  CAS  Google Scholar 

  17. Yaqoob, P., Newsholme, E.A., and Calder, P.C. (1994) Inhibition of Natural Killer Cell Activity by Dietary Lipids,Immunol. Lett. 41, 241–247.

    Article  PubMed  CAS  Google Scholar 

  18. Billiar, T., Bankey, P., Svingen, B., Curran, R.D., West, M.A., Holman, R.T., Simmons, R.L., and Cerra, F.B. (1988) Fatty Acid Uptake and Kupffer Cell Function: Fish Oil Alters Eicosanoid and Monokine Production to Endotoxin Stimulation,Surgery 104, 343–349.

    PubMed  CAS  Google Scholar 

  19. Yaqoob, P., and Calder, P.C. (1995) Effects of Dietary Lipid Manipulation upon Inflammatory Mediator Production by Murine Macrophages,Cell. Immunol. 163, 120–128.

    Article  PubMed  CAS  Google Scholar 

  20. Renier, G., Skamene, E., de Sanctis, J., and Radzioch, D. (1993) Dietary n-3 Polyunsaturated Fatty Acids Prevent the Development of Atherosclerotic Lesions in Mice: Modulation of Macrophage Secretory Activities,Arterioscler. Thomb. 13, 1515–1524.

    CAS  Google Scholar 

  21. Somers, S.D., Chapkin, R.S., and Erickson, K.L. (1989) Alteration ofin vitro Murine Peritoneal Macrophage Function by Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids in Menhaden Fish Oil,Cell. Immunol. 123, 201–211.

    Article  PubMed  CAS  Google Scholar 

  22. Black, J.M., and Kinsella, J.E. (1993) Dietary n-3 Fatty Acids Alter Mouse Peritoneal Macrophage Cytotoxicity,Ann. Nutr. Metab. 37, 110–120.

    Article  PubMed  CAS  Google Scholar 

  23. Peterson, L.D., Jeffery, N.M., Thies, F., Sanderson, P., Newsholme, E.A., and Calder, P.C. (1998) Eicosapentaenoic and Docosahexaenoic Acids Alter Rat Spleen Leukocyte Fatty Acid Composition and Prostaglandin E2 Production but Have Different Effects on Lymphocyte Functions and Cell-Mediated Immunity,Lipids 33, 171–180.

    Article  PubMed  CAS  Google Scholar 

  24. Peterson, L.D., Thies, F., Sanderson, P., Newsholme, E.A., and Calder, P.C. (1998) Low Levels of Eicosapentaenoic and Docosahexaenoic Acids Mimic the Effects of Fish Oil upon Rat Lymphocytes,Life Sci. 62, 2209–2217.

    Article  PubMed  CAS  Google Scholar 

  25. Marshall, L.A., and Johnston, P.V. (1985) The Influence of Dietary Essential Fatty Acids on Rat Immunocompetent Cell Prostaglandin Synthesis and Mitogen-Induced Blastogenesis.J. Nutr. 115, 1572–1580.

    PubMed  CAS  Google Scholar 

  26. Jeffery, N.M., Sanderson, P., Sherrington, E.J., Newsholme, E.A., and Calder, P.C. (1996) The Ratio of n-6 to n-3 Polyunsaturated Fatty Acids in the Rat Diet Alters Serum Lipid Levels and Lymphocyte Functions,Lipids 31, 737–745.

    Article  PubMed  CAS  Google Scholar 

  27. Jeffery, N.M., Newsholme, E.A., and Calder, P.C. (1997) The Level of Polyunsaturated Fatty Acids and the n-6 to n-3 Polyunsaturated Fatty Acid Ratio in the Rat Diet both Affect Serum Lipid Levels and Lymphocyte Functions,Prostaglandins Leukotrienes Essent. Fatty Acids 57, 149–160.

    Article  CAS  Google Scholar 

  28. Jeffery, N.M., Sanderson, P., Newsholme, E.A., and Calder, P.C. (1997) Effects of Varying the Type of Saturated Fatty Acid in the Rat Diet upon Serum Lipid Levels and Spleen Lymphocyte Functions,Biochim. Biophys. Acta 1345, 223–236.

    PubMed  CAS  Google Scholar 

  29. Jeffery, N.M., Cortina, M., Newsholme, E.A., and Calder, P.C. (1997) Effects of Variations in the Proportions of Saturated, Monounsaturated and Polyunsaturated Fatty Acids in the Rat Diet upon Spleen Lymphocyte Functions,Br. J. Nutr. 77, 805–823.

    Article  PubMed  CAS  Google Scholar 

  30. Meydani, S.N., Endres, S., Woods, M.M., Goldin, B.R., Soo, C., Morrill-Labrode, A., Dinarello, C., and Gorbach, S.L. (1991) Oral (n-3) Fatty Acid Supplementation Suppresses Cytokine Production and Lymphocyte Proliferation: Comparison Between Young and Older Women,J. Nutr. 121, 547–555.

    PubMed  CAS  Google Scholar 

  31. Meydani, S.N., Lichtenstein, A.H., Cornwall, S., Meydani, M., Goldin, B.R., Rasmussen, H., Dinarello, C.A., and Schaefer, E.J. (1993) Immunologic Effects of National Cholesterol Education Panel Step-2 Diets With and Without Fish-Derived n-3 Fatty Acid Enrichement,J. Clin. Invest. 92, 105–113.

    PubMed  CAS  Google Scholar 

  32. Endres, S., Meydani, S.N., Ghorbani, R., Schindler, R., and Dinarello, C.A. (1993) Dietary Supplementation with n-3 Fatty Acids Suppresses Interleukin-2 Production and Mononuclear Cell Proliferation,J. Leukocyte Biol. 54, 599–603.

    PubMed  CAS  Google Scholar 

  33. Endres, S., Ghorbani, R., Kelley, V.E., Georgilis, K., Lonemann, G., van der Meer, J.M.W., Cannon, J.G., Rogers, T.S., Klempner, M.S., Weber, P.C., Schaeffer, E.J., Wolff, S.M., and Dinarello, C.A. (1989) The Effect of Dietary Supplementation with n-3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells,N. Engl. J. Med. 320, 265–271.

    Article  PubMed  CAS  Google Scholar 

  34. Lee, T.H., Hoover, R.L., Williams, J.D., Sperling, R.I., Ravalese, J., Spur, B.W., Robinson, D.R., Corey, E.J., Lewis, R.A., and Austen, K.F. (1985) Effects of Dietary Enrichment with EPA and DHA onin vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function,N. Engl. J. Med. 312, 1217–1224.

    Article  PubMed  CAS  Google Scholar 

  35. Schmidt, E.B., Pederson, J.O., Ekelund, S., Grunnet, N., Jersild, C., and Dyerberg, J., (1989) Cod Liver Oil Inhibits Neutrophil and Monocyte Chemotaxis in Healthy Males,Atherosclerosis 77, 53–57.

    Article  PubMed  CAS  Google Scholar 

  36. Sperling, R.I., Benincaso, A.I., Knoell, C.T., Larkin, J.K., Austen, K.F., and Robinson, D.R. (1989) Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Phosphoinositide Formation and Chemotaxis in Neutrophils,J. Clin. Invest. 91, 651–660.

    Article  Google Scholar 

  37. Caughey, G.E., Mantzioris, E., Gibson, R.A., Cleland, L.G., and James, M.J. (1996) The Effect on Human Tumor Necrosis Factor α and Interleukin 1β Production of Diets Enriched in n-3 Fatty Acids from Vegetable Oil or Fish Oil,Am. J. Clin. Nutr. 63, 116–122.

    PubMed  CAS  Google Scholar 

  38. De Caterina, R., Cybulsky, M.I., Clinton, S.K., Gimbrone, M.A., and Libby, P. (1994) The Omega-3 Fatty Acid Docosahexaenoate Reduces Cytokine-Induced Expression of Proatherogenic and Proinflammatory Proteins in Human Endothelial Cells,Arterioscler. Thromb. 14, 1829–1836.

    PubMed  Google Scholar 

  39. Hughes, D.A., Southon, S., and Pinder, A.C. (1996) (n-3) Polyunsaturated Fatty Acids Modulate the Expression of Functionally Associated Molecules on Human Monocytesin vitro, J. Nutr. 126, 603–610.

    PubMed  CAS  Google Scholar 

  40. Khalfoun, B., Thibault, G., Bardos, P., and Lebranchu, Y. (1996) Docosahexaenoic and Eicosapentaenoic Acids Inhibitin vitro Human Lymphocyte-Endothelial Cell Adhesion,Transplantation 62, 1649–1657.

    Article  PubMed  CAS  Google Scholar 

  41. Sanderson, P., Yaqoob, P., and Calder, P.C. (1995) Effects of Dietary Lipid Manipulation upon Graft vs. Host and Host vs. Graft Responses in the Rat,Cell. Immunol. 164, 240–247.

    Article  PubMed  CAS  Google Scholar 

  42. Hughes, D.A., Pinder, A.C., Piper, Z., Johnson, I.T., and Lund, E.K. (1996) Fish Oil Supplementation Inhibits the Expression of Major Histocompatibility Complex Class II Molecules and Adhesion Molecules on Human Monocytes,Am. J. Clin. Nutr. 63, 267–272.

    PubMed  CAS  Google Scholar 

  43. Sanderson, P., and Calder, P.C. (1998) Dietary Fish Oil Diminishes Lymphocyte Adhesion to Macrophage and Endothelial Cell Monolayers,Immunology 94, 79–87.

    Article  PubMed  CAS  Google Scholar 

  44. Grimble, R.F. (1996) Interaction Between Nutrients, Pro-Inflammatory Cytokines and Inflammation,Clin. Sci. 91, 121–130.

    PubMed  CAS  Google Scholar 

  45. Mascioli, E.A., Leader, L., Flores, E., Trimbo, S., Bistrian, B., and Blackburn, G. (1988) Enhanced Survival to Endotoxin in Guinea Pigs Fed IV Fish Oil Emulsion,Lipids 23, 623–625.

    Article  PubMed  CAS  Google Scholar 

  46. Mascioli, E.A., Iwasa, Y., Trimbo, S., Leader, L., Bistrian, B.R., and Blackburn, G.L. (1989) Endotoxin Challenge After Menhaden Oil Diet: Effects on Survival of Guinea Pigs,Am. J. Clin. Nutr. 49, 277–282.

    PubMed  CAS  Google Scholar 

  47. Hellerstein, M.K., Meydani, S.N., Meydani, M., Wu, K., and Dinarello, C.A. (1989) Interleukin-1-Induced Anorexia in the Rat: Influence of Prostaglandins,J. Clin. Invest. 84, 228–235.

    PubMed  CAS  Google Scholar 

  48. Mulrooney, H.M., and Grimble, R.F. (1993) Influence of Butter and of Corn, Coconut, and Fish Oils on the Effects of Recombinant Human Tumour Necrosis Factor-α in Rats,Clin. Sci. 84, 105–112.

    PubMed  CAS  Google Scholar 

  49. Kelley, V.E., Ferretti, A., Izui, S., and Strom, T.B. (1985) A Fish Oil Diet Rich in Eicosapentaenoic Acid Reduces Cyclooxygenase Metabolites and Suppresses Lupus in MRL-lpr Mice,J. Immunol. 134, 1914–1919.

    PubMed  CAS  Google Scholar 

  50. Fernandes, G., Bysani, C., Venkatraman, J.T., Tomar, V., and Zhao, W. (1994) Increased TGF-β and Decreased Oncogene Expression by ω-3 Fatty Acids in the Spleen Delays Onset of Autoimmune Disease in B/W Mice,J. Immunol. 152, 5979–5987.

    PubMed  CAS  Google Scholar 

  51. Chandrasekar, B., and Fernandes, G. (1994) Decreased Pro-Inflammatory Cytokines and Increased Antioxidant Enzyme Gene Expression by ω-3 Lipids in Murine Lupus Nephritis,Biochem. Biophys. Res. Commun. 200, 893–898.

    Article  PubMed  CAS  Google Scholar 

  52. Miles, E.A., and Calder, P.C. (1998) Modulation of Immune Function by Dietary Fatty Acids,Proc. Nutr. Soc. 57, 277–292.

    Article  PubMed  CAS  Google Scholar 

  53. Yaqoob, P. (1998) Lipids and the Immune Response,Curr. Opin. Clin. Nutr. Metab. Care 1, 153–161.

    Article  PubMed  CAS  Google Scholar 

  54. Roper, R.L., and Phipps, R.P. (1994) Prostaglandin E2 Regulation of the Immune Response,Adv. Prost. Thromb. Leukotr. Res. 22, 101–111.

    CAS  Google Scholar 

  55. Kinsella, J.E., Lokesh, B., Broughton, S., and Whelan, J. (1990) Dietary Polyunsaturated Fatty Acids and Eicosanoids: Potential Effects on the Modulation of Inflammatory and Immune Cells: An Overview,Nutrition 6, 24–44.

    PubMed  CAS  Google Scholar 

  56. Lewis, R.A., Austen, K.F., and Soberman R.J. (1993) Leukotrienes and Other Products of the 5-Lipoxygenase Pathway: Biochemistry and Relation to Pathobiology in Human Diseases,N. Engl. J. Med. 323, 645–655.

    Google Scholar 

  57. Hwang, D. (1989) Essential Fatty Acids and the Immune Response,FASEB J. 3, 2052–2061.

    PubMed  CAS  Google Scholar 

  58. Sanderson, P., and Calder, P.C. (1998) Dietary Fish Oil Appears to Prevent the Activation of Phospholipase C-γ in Lymphocytes,Biochim. Biophys. Acta 1392, 300–308.

    PubMed  CAS  Google Scholar 

  59. Bechoua, S., Dubois, M., Nemoz, G., Lagrade M., and Prigent, A.-F. (1998) Docosahexaenoic Acid Lowers Phosphatidate Level in Human-Activated Lymphocytes Despite Phospholipase D Activation,J. Lipid Res. 39, 873–883.

    PubMed  CAS  Google Scholar 

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Calder, P.C. Dietary fatty acids and the immune system. Lipids 34 (Suppl 1), S137–S140 (1999). https://doi.org/10.1007/BF02562264

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