Abstract
Thirty patients who had curative surgery for sigmoid and rectal carcinoma were studied by immunoscintigraphy using a new monoclonal antibody: B72.3 radiolabeled with Iodine-131 (I-131) or Indium-111 (In-111). Results were compared with other conventional diagnostic procedures such as computed tomography, ultrasound, endoscopy, and tumor markers. Seven patients had local recurrences and/or distant metastases. Immunoscintigraphy identified all local recurrences (five cases) that were confirmed by CT and was able to localize three of five liver metastases (two false-negatives). Furthermore, immunoscintigraphy also recorded a false-positive. Preliminary use of B72.3 shows good potential for the evaluation and detection of neoplastic sites.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Goldenberg DM, Deland F, Kim E, et al. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med 1978; 298:1384–8.
Van Nagell JR, Kim E, Casper S, et al. Radioimmunodetection of primary and metastatic ovarian cancer using radiolabeled antibodies to carcinoembryonic antigen. Cancer Res 1980;40:502–5.
Wahl RL, Parker CW, Philpott GA. Improved radioimaging and tumor localization with monoclonal F(ab′)2. J Nucl Med 1983;24:316–25.
Chatal JF, Saccavini JC, Fumoleau P, et al. Immunoscintigraphy of colon carcinoma. J Nucl Med 1984;25:307–14.
Bucci L, Salvatore M, Grigioni W, Gentile M, Mazzeo F. New trends in prestaging of colorectal cancer and early detection of local recurrences. IV International Symposium of Digestive Surgery and Endoscopy. (Università La Sapienza, Rome; Thomas Jefferson University, Philadelphia). Abst. 1986;1–41.
Author information
Authors and Affiliations
Additional information
Read at the 1th Biennial Congress of the International Society of University Colon and Rectal Surgeons, Dallas, Texas, May 4 to 8, 1986.
Supported in part by a grant of CNR, Progetto Finalizzato “Oncologia,” Sottoprogetto 7.
About this article
Cite this article
Renda, A., Salvatore, M., Sava, M. et al. Immunoscintigraphy in the follow-up of patients operated on for carcinoma of the sigmoid and rectum. Dis Colon Rectum 30, 683–686 (1987). https://doi.org/10.1007/BF02561688
Issue Date:
DOI: https://doi.org/10.1007/BF02561688