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Analysis of the acute cytotoxicity of the erlanger silver catheter

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Summary

The Erlanger silver catheter consists of a new form of polyurethane, which contains finely dispersed metallic silver. The aim of this study was to establish the biocompatibility of this intravenous catheter by investigating the acute cytotoxicity of extracts from the Erlanger silver catheter on human fibroblasts and lymphocytes. Extracts of the Erlanger silver catheter were not cytotoxic for MRC-5 human fibroblasts nor for sensitized phytohem-agglutinin (PHA)-stimulated human lymphocytes. The addition of silver powder of up to 2% by weight to the basic catheter polyurethane TecothaneTM led to no increase in acute cytotoxicity in comparison with untreated TecothaneTM. The Erlanger silver catheter is a new intravenous catheter with good biocompatibility.

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References

  1. Bach, A., Böhrer, H.: Infektionen durch intravasale Katheter. Anästesiol. Intensivmed. Notfallmed. Schmerzther. 28 (1993) 404–414.

    Article  CAS  Google Scholar 

  2. Bach, A., Böhrer, H., Motsch, J., Geiss, H. K., Martin, E., Sonntag, H. G.: Prevention of bacterial colonization of intravenous catheters by aseptic impregnation of polyurethane polymers. J. Antimicrob. Chemother. 33 (1994) 969–978.

    Article  PubMed  CAS  Google Scholar 

  3. Pettigrew, R. A., Lang, S. D. R., Haydock, D. A., Parry, B. R., Bremner, D. A., Hill, G. L.: Catheter related sepsis in patients on intravenous nutrition: a prospective study of quantitative catheter cultures and guidewire changes for suspected sepsis. Br. J. Surg. 72 (1985) 52–55.

    PubMed  CAS  Google Scholar 

  4. Norwood, S., Ruby, A., Civetta, J., Cortes, V.: Catheter-related infections and associated septicemia. Chest 99 (1991) 968–975.

    PubMed  CAS  Google Scholar 

  5. Williams, R. L., Doherty, P. J., Vince, D. G., Grashoff, G. J., Williams, D. F.: The biocompatibility of silver. Critical Reviews in Biocompatibility 5 (1989) 221–243.

    CAS  Google Scholar 

  6. Biological Evaluation of Medical Devices—Part 5: Tests for cytotoxicity,in vitro methods. 1st ed. 1992 (Reference number ISO 10993-5: 1992 (E)).

  7. The United States Pharmacopeial Convention, Inc.: Official reference standards (effective: February 9, 1995).

  8. Mossman, T.: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65 (1983) 55–63.

    Article  Google Scholar 

  9. Steffensen, I. L., Mesna, O. J., Andruchow, E., Namork, E., Hylland, K., Andersen, R. A.: Cytotoxicity and accumulation of Hg, Ag, Cd, Cu, Pb and Zn in human peripheral T and B lymphocytes and monocytesin vitro. Gen. Pharmac. 25 (1994) 1621–1633.

    CAS  Google Scholar 

  10. Zhao, G., Stevens, E.: Multiple parameters for the comprehensive evaluation of the susceptibility ofEscherichia coli to the silver ion. BioMetals 11 (1999) 27–32.

    Article  Google Scholar 

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Authors and Affiliations

  1. Klinik mit Poliklinik für Kinder und Jugendliche, Friedrich-Alexander-Universität Erlangen-Nürnberg, Loschgestr. 15, D-91054, Erlangen, Germany

    J. Greil, T. Spies,  M. Böswald,  T. Bechert,  S. Lugauer,  A. Regenfus &  J. -P. Guggenbichler

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  1. J. Greil
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  2. T. Spies
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  3. M. Böswald
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  4. T. Bechert
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  5. S. Lugauer
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  6. A. Regenfus
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  7. J. -P. Guggenbichler
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Greil, J., Spies, T., Böswald, M. et al. Analysis of the acute cytotoxicity of the erlanger silver catheter. Infection 27 (Suppl 1), S34–S37 (1999). https://doi.org/10.1007/BF02561615

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  • DOI: https://doi.org/10.1007/BF02561615

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