Summary
Cytomegalovirus (CMV)-associated transverse myelitis is rare in immunocompetent patients. The case of a 54-year-old man is reported here who developed acute transverse myelitis with cerebrospinal fluid (CSF) alterations, suggesting a central nervous system infection. CMV-IgM positivity in serum and CMV isolated from blood, positive CMV PCR and positivity for pp65 antigen in blood, without viral antigens in the CSF and a positive response to therapy with ganciclovir (followed by progressive improvement) supported the diagnosis.
Similar content being viewed by others
References
Eddleston, M., Peacock, S., Juniper, M., Warrel, D. A.: Severe cytomegalovirus infection in immunocompetent patients. CID 24 (1997) 52–56.
Miles, C., Hoffmann, W., Chi-Wan Lai: Cytomegalovirus-associated transverse myelitis. Neurology 43 (1993) 21–43.
Shahid, M. B., Ata Kan, M.: Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient. J. Neurol. Sci. 134 (1995) 1210–211.
Chin, W., Magoffin, R., Frierson, J. G., Lennette, E. H.: Cytomegalo-virus infection: a case with meningoencephalitis. JAMA 225 (1973) 740–741.
Kabins, S., Keller, R., Naragi, S., Peitchel, R.: Viral ascending radiculomyelitis with severe hypoglycorrachia. Arch. Intern. Med. 136 (1976) 933–935.
Tyler, K. L., Gross, R. A., Cascino, G. D.: Unusual viral cases of transverse myelitis: hepatitis A and CMV. Neurology 36 (1986) 855–858.
Douglas, R. J., Raul, N. M., Larry, E. D.: Transverse myelitis, Arch. Neurol. 50 (1993) 532–535.
Jacobson, M. A.: Ganciclovir therapy for severe cytomegalovirus infection in immunocompetent patients (letter). CID 25 (1997) 1487–1488.
Steven, J. R., Jeffery, K. J. M., Bangham, C. R. M.: Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. J. Clin. Microbiol. 35 (1997) 691–696.
Cinque, P., Lazzarin, A.: Polymerase chain reaction (PCR) su liquido cerebrospinale nella diagnosi delle infezioni virali del sistema nervoso centrale. Giorn. It. Mal. Inf. 1 (1995) 261–268.
Gerna, G.: Monitoraggio virologico delle infezioni sistemiche da Cytomegalovirus umano nel paziente con AIDS. GIADIS 2 (1992) 150–159.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giobbia, M., Carniato, A., Scotton, P.G. et al. Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient. Infection 27, 228–230 (1999). https://doi.org/10.1007/BF02561538
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02561538