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Significance of hepatic pedicle lymph node involvement in patients with colorectal liver metastases: A prospective study

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Abstract

Background

We investigated whether hepatic pepticle lymph node (HP-LN) involvement is a more significant prognostic factor and whether HP-LN dissection could be efficient in patients with positive HP-LN involvement.

Methods

From 1988 to 1998, HP-LN dissection was prospectively performed in 160 patients undergoing hepatectomy for colorectal liver metastases. Survival of patients with HP-LN involvement limited to the hepatoduodenal ligament and retropancreatic portion (area 1) was compared with that of patients with HP-LN involvement spreading over the common hepatic artery and celiac axis (area 2).

Results

HP-LN involvement was detected in 17 patients. The survival rate was significantly lower in patients with HP-LN involvement. HP-LN involvement was the most significant prognostic factor. Survival was significantly higher in patients with HP-LN involvement limited to area 1 than in those with HP-LN involvement spreading over area 2.

Conclusions

HP-LN involvement was the most significant prognostic indicator in patients with colorectal liver metastases. Positive LNs of area 1 should no longer be considered an absolute contraindication to liver resection, but in case of area 2 lymph node involvement, liver resection does not seem justified.

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Authors and Affiliations

  1. Service d’Anatomie Pathologique, Hôpital de Hautepierre, Strasbourg, France

    Marie-Pierre Chenard-Neu MD, PhD

  2. Centre de Chirurgie Viscérale et de Transplantation, Hôpital de Hautepierre, Avenue Molière, 67098, Strasbourg Cedex, France

    Daniel Jaeck MD, PhD, Hiroshi Nakano MD, PhD, Philippe Bachellier MD, Keiichiro Inoue MD, Jean-Christophe Weber MD, Elie Oussoultzoglou MD & Philippe Wolf MD, PhD

Authors
  1. Daniel Jaeck MD, PhD
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  2. Hiroshi Nakano MD, PhD
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  3. Philippe Bachellier MD
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  4. Keiichiro Inoue MD
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  5. Jean-Christophe Weber MD
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  6. Elie Oussoultzoglou MD
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  7. Philippe Wolf MD, PhD
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  8. Marie-Pierre Chenard-Neu MD, PhD
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Correspondence to Daniel Jaeck MD, PhD.

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Jaeck, D., Nakano, H., Bachellier, P. et al. Significance of hepatic pedicle lymph node involvement in patients with colorectal liver metastases: A prospective study. Annals of Surgical Oncology 9, 430–438 (2002). https://doi.org/10.1007/BF02557264

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  • DOI: https://doi.org/10.1007/BF02557264

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