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Age-related bone loss in lumbar vertebrae of CW-1 female mice: A histomorphometric study

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Summary

Age-related changes in vertebral cortical and trabecular bone were quantitated in female CW-1 mice. Histomorphometric measurements involved the use of two different systems of image analysis: Olympus Cue 2 and Zeiss Morphomat 10. The peak of bone mass, both cortical and trabecular, was found in mice aged 13.5 months. Thereafter, there was a progressive decline in the area occupied by bone tissue and this became highly significant in elderly female and male mice. A loss of about 60% of bone tissue was encountered in both the trabecular and cortical bone, as determined by automated image analysis system. Hence, aging CW-1 mice reveal structural features consistent with vertebral osteopenia. Despite the fact that to date we lack the precise etiology for the abovementioned phenomenon, it is suggested that the laboratory mouse might serve as an appropriate experimental model for investgations related to agerelated bone loss.

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Authors and Affiliations

  1. Laboratory for Musculoskeletal Research, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Haifa, Israel

    B. Bar-Shira-Maymon, R. Coleman &  M. Silbermann

  2. Faculty of Industrial and Management Engineering, Technion-Israel Institute of Technology, Haifa, Israel

    A. Cohen

  3. Eppendorf University Hospital, Hamburg, Federal Republic of Germany

    E. Steinhagen-Thiessen

Authors
  1. B. Bar-Shira-Maymon
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  2. R. Coleman
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  3. A. Cohen
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  4. E. Steinhagen-Thiessen
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  5. M. Silbermann
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Additional information

This study was presented in part at the IXth International Congress on Calcium Regulating Hormones and Bone Metabolism, Nice, France, October 1986, and at the 5th Annual Meeting of the Japanese Society for Bone and Mineral Research, Tokyo, August, 1987.

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Bar-Shira-Maymon, B., Coleman, R., Cohen, A. et al. Age-related bone loss in lumbar vertebrae of CW-1 female mice: A histomorphometric study. Calcif Tissue Int 44, 36–45 (1989). https://doi.org/10.1007/BF02556238

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  • DOI: https://doi.org/10.1007/BF02556238

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