Summary
Synthetic human calcitonin gene-related peptide (CGRP) was examined for the action on the bonein vitro. Human CGRP inhibited bone resorption stimulated by both human parathyroid hormone and basal. The mode of inhibitory action of human CGRP seemed to be similar to that of calcitonin and the relative potency of human CGRP to inhibit bone resorption is one five-hundredth of that of human calcitonin. Thus, a novel pharmacological action of CGRP was demonstrated.
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References
Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129–135.
Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244
Morris HR, Panico M, Etienne T, Tippins J, Girgis SI, MacIntyre I (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308:746–748
Fisher LA, Kikkawa DO, Rivier JE, Amara SG, Evans RM, Rosenfeld MG, Vale WW, Brown MR (1983) Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature 306:534–536
Evans RM, Amara SG, Rosenfeld MG (1983) Molecular events in developmental regulation of neuroendocrine genes: characterization of the novel neuropeptide CGRP. Cold Spring Harbor Symp Quat Biol 48:413–417
Copp D (1970) Endocrine regulation of calcium metabolism. Ann Rev Physiol 32:61–85
Fujii N, Yajima H, Otaka A, Funakoshi S, Nomizu M, Akaji K, Yamamoto I, Torizuka K, Kitagawa K, Akita T, Ando K, Kawamoto T, Shimonishi Y, Takao T, (1985) Application of S-I-adamantyleysteine to the synthesis of a 37-residue peptide amide corresponding to human calcitonin gene-related peptide. J Chem Soc Chem Commun, 602–603
Shigeno C, Yamamoto I, Dokoh S, Hino M, Aoki J, Torizuka K, Kameyama M (1985) Identification of 1,24(R)-dihydroxyvitamin D3-like bone-resorbing lipid in a patient with cancer-associated hypercalcemia. J Clin Endocrinol Metab 61:761–768
Rittel W, Maier R, Brugger M, Kamber B, Riniker B, Sieber P (1976) Structure-activity relationship of human calcitonin III: biological activity of synthetic analogues with shortened or terminally modified peptide chains. Experientia 32:246–248
Goltzman D, Mitchell, J (1985) Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues. Science 227:1343–1345
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Yamamoto, I., Kitamura, N., Aoki, J. et al. Human calcitonin gene-related peptide possesses weak inhibitory potency of bone resorptionin vitro . Calcif Tissue Int 38, 339–341 (1986). https://doi.org/10.1007/BF02555747
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DOI: https://doi.org/10.1007/BF02555747