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Calcitonin gene-related peptide inhibits osteoclastic bone resorption: A comparative study

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Summary

Besides the calcitonin (CT) precursor, the calcitonin gene also encodes another peptide—calcitonin gene-related peptide (CGRP). We have previously reported that CGRP lowers plasma calcium in the rat. In the present study we have evaluated the effect of CGRP on resorption of bone by isolated rat osteoclasts and have compared these effects to those produced by calcitonins from three species (salmon, pig, and human calcitonins). There was a significant inhibition of bone resorption with rat calcitonin gene-related peptide (rCGRP) at a 1000-fold higher dose than that used for human CT. This effect well explains the CT-like effect of CGRP seen in thein vivo rat CT bioassay. Our results suggest that though CGRP may not be involved in the hormonal control of plasma calcium, the peptide may be an important local regulator of bone cell function.

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Authors and Affiliations

  1. Endocrine Unit, Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, DuCane Road, W12 OHS, London, (UK)

    Mone Zaidi, Peter J. R. Bevis & Iain MacIntyre

  2. Department of Histopathology, St. Georges Hospital Medical School, Crammer Terrace, SW17, London

    Karen Fuller & Timothy J. Chambers

  3. National Institute of Biological Standards and Control, Holly Hill, London

    Rose E. GainesDas

Authors
  1. Mone Zaidi
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  2. Karen Fuller
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  3. Peter J. R. Bevis
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  4. Rose E. GainesDas
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  5. Timothy J. Chambers
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  6. Iain MacIntyre
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Zaidi, M., Fuller, K., Bevis, P.J.R. et al. Calcitonin gene-related peptide inhibits osteoclastic bone resorption: A comparative study. Calcif Tissue Int 40, 149–154 (1987). https://doi.org/10.1007/BF02555699

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  • DOI: https://doi.org/10.1007/BF02555699

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