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Colorectal cancer in patients younger than 40 years of age

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Diseases of the Colon & Rectum

Abstract

To assess prognostic factors in patients who develop colorectal cancer before the age of 40 years, a 30-year experience from 1956 through 1985 was reviewed. There were 50 patients ranging in age from 7 to 39 years. Five cases were associated with either ulcerative colitis (2) or familial polyposis (3). The most common presenting symptoms were abdominal pain (66 percent), hermatochezia (60 percent), change in bowel habit (41 percent) and weight loss (30 percent). On pathologic staging (N=44), only 14 of 44 (31 percent) had a Dukes' stage A on B lesion, 20 (45 percent) had Dukes' stage C, and the remaining 10 (23 percent) had distant metastases at the time of surgery. Fiveyear survival rate was 28 percent with a disease-free survival rate of 18 percent. Median survival was only 28 months. Negative prognostic tactors were Dukes' stage C/D (P<0.01), symptom duration of longer than 3 months (P=01), noncaucasian ancestry (P=0.1), and poorly differentiated histology (P=06). In contrast to older patients with colorectal cancer, only 1 of 30 (3 percent) patients with stage C/D disease was disease-free at 5 years. In view of the poor survival rate associated with both delay in diagnosis and the presence of advanced disease, it was concluded that young patients presenting with the symptoms listed above need early, aggressive evabuation for possible colorectal cancer

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Authors and Affiliations

  1. Department of Surgery, Harbor-UCLA Medical Center, 1000 West Carson Street, Box 25, Torrance, California, 90509

    Craig Smith M.D. &  John A. Butler M.D.

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  1. Craig Smith M.D.
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  2. John A. Butler M.D.
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Smith, C., Butler, J.A. Colorectal cancer in patients younger than 40 years of age. Dis Colon Rectum 32, 843–846 (1989). https://doi.org/10.1007/BF02554552

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