Abstract
Malignant fibrous histiocytoma is a pleomorphic sarcoma that classically arises in the extremities and metastasizes to the lungs and regional lymph nodes. A review of the literature revealed only four previous cases of primary gastrointestinal malignant fibrous histiocytoma, all of which were treated by resection. This report describes a unique case arising in the anal sphincter that was treated by abdominoperineal resection and radiotherapy. The pathology of the condition, including immunocytochemical methods used to identify the tumor and its likely cell of origin, is discussed. The importance of long-term follow-up with repeated chest x-ray andlocal lymph-node examination is emphasized.
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References
O'Brien JE, Stout AP. Malignant fibrous xanthomas. Cancer 1964;17:1445–55.
Stout AP, Lattes R. Tumors of the soft tissues. In: Altas of tumor pathology, second series, fasc 1. Washington: Armed Forces Institute of Pathology 1967:38–52;107–15.
Weiss SW, Enzinger FM. Myxoid variant of malignant fibrous histiocytoma. Cancer 1977;39:1672–85.
Roholl PJ, Kleyne J, Elbers H, Van Der Vegt MC, Albus-Lutter C, Van Unnik JA. Characterization of tumor cells in malignant fibrous histiocytomas and other soft tissue tumors in comparison with malignant histocytes. I. Immunohistochemical study on paraffin sections. J Pathol 1985;147:87–95.
Weiss SW, Enzinger FM. Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer 1978;41:2250–66.
Wasserman TH, Stuard ID. Malignant fibrous histiocytoma with widespread metastases: autopsy study. Cancer 1974;33:141–6.
Soule EH, Enriquez P. Atypical fibrous histiocytoma, malignant fibrous histocytoma, malignant histiocytoma, and epithelioid sarcoma: a comparative study of 65 tumors. Cancer 1972;30:128–43.
Levinson MM, Tsang D. Multicentric malignant fibrous histiocytomas of the colon: report of a case and review of the subject. Dis Colon Rectum 1982;25:327–31.
Margules RM, Allen RE, Dunphy JE. Pancreastic tumor of mesenchymal origin presenting as obstructive jaundice. Am J Surg 1976;131:357–9.
Verma P, Chandra U, Bhatia PS. Malignant fibrous histiocytoma of the rectum: report of a case. Dis Colon Rectum 1979;22:179–82.
Musiej-Nowakowska E, Woszczyk W, Gizycka I. Histiocytoma malignum ventriculi u 8-letneigo chlopca. Paediatr Pol 1973;48:85–8.
Kempson RL, Kyriakos M. Fibroxanthosarcoma of the soft tissues. Cancer 1972;29:961–76.
Kauffman S, Stout AP. Histiocytic tumors (fibrous xanthoma and histiocytoma) in children. Cancer 1961;14:469–82.
Fu YS, Gabbiani G, Kaye GI, Lattes R. Malignant soft tissue tumors of probable histiocyte origin (malignant fibrous histiocytomas): general considerations and electron microscopic and tissue culture studies. Cancer 1975;35:176–98.
Ozzello L, Stout AP, Murray MR. Cultural characteristics of malignant fibrous histiocytomas and fibrous xanthomas. Cancer 1963;16:331–4.
Ekfors TO, Rantakokko V. An analysis of 38 malignant fibrous histiocytomas in the extremities. Acta Pathol Microbiol Scand [A] 1978;86:25–35.
Leite C, Goodwin JW, Sinkovics JG, Baker LH, Benjamin R. Chemiotherapy of malignant fibrous histiocytoma: a Southwest Oncology Group report. Cancer 1975;40:2010–14.
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Flood, H.D., Salman, A.A. Malignant fibrous histiocytoma of the anal canal. Dis Colon Rectum 32, 256–259 (1989). https://doi.org/10.1007/BF02554541
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DOI: https://doi.org/10.1007/BF02554541