Skip to main content

Advertisement

SpringerLink
Log in

Effects of high-dose and low-dose preoperative irradiation on low anterior anastomoses in dogs

  • Published:
Diseases of the Colon & Rectum

Abstract

Twenty mongrel dogs underwent preoperative irradiation to the colon and rectum, receiving 4000 rads according to the Nominal Standard Dose Equation. Each dog then underwent anterior resection of the rectosigmoid, and reconstructive technique was randomized into two groups consisting of either handsewn or EEA-stapled anastomoses. Anastomoses were examined digitally and radiographically at the time of surgery and on the seventh postoperative day. There were four radiographic leaks among the handsewn anastomoses, but only one was clinically significant and associated with peritonitis. There were no leaks among the ten EEA-stapled anastomoses. The data suggest that low anterior resection and anastomosis can be done safely after 4000 rad irradiation and that the EEA-stapled anastomosis may be preferable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allen CV, Fletcher WS. A pilot study on preoperative irradiation of rectosigmoid carcinoma. AJR 1972;114:504–8.

    CAS  Google Scholar 

  2. Friedmann P, Park WC, Afonya II, et al. Adjuvant radiation therapy in colorectal carcinoma. AM J Surg 1978;135:512–8.

    Article  PubMed  CAS  Google Scholar 

  3. Green JP. Rectal cancer adjuvant radiation therapy. In: What's new in cancer care. 1979;3:1.

  4. Higgins GA Jr, Conn JH, Jordan PH Jr, Humphrey EW, Roswitz B, Keehn RJ. Preoperative radiotherapy for colorectal cancer. Ann Surg 1975;181:624–31.

    Article  PubMed  Google Scholar 

  5. Higgins GA Jr. The pros and cons of irradiation treatment of colorectal cancer. Surg Annu 1978;10:175–90.

    PubMed  Google Scholar 

  6. Jackson BR. Contemporary management of rectal cancer: an overview. Cancer 1977;40:2365–74.

    Article  PubMed  CAS  Google Scholar 

  7. Kligerman MM, Urdaneta N, Knowlton A, Vidone R, Hartman PV, Vera R. Preoperative irradiation of rectosigmoid carcinoma including its regional lymph nodes. AJR 1972;114:498–503.

    CAS  Google Scholar 

  8. Leaming RH, Stearns MW Jr, Deddish MR. Preoperative irradiation in rectal carcinoma. Radiology 1961;77:257–63.

    PubMed  CAS  Google Scholar 

  9. Motiuddin M, Kramer S. Adjuvant radiotherapy—preoperative, postoperative, or both: a proposal for a new approach. Cancer Clin Trials 1978 Summer;1:93–7.

    Google Scholar 

  10. Photopulos GJ, Delgado G, Fowler WC Jr, Walton LA. Intestinal anastomoses after radiation therapy by surgical stapling instruments. Obstet Gynecol 1979;54:515–8.

    PubMed  CAS  Google Scholar 

  11. Pilepich MV, Munzenrider JE, Tak WK, Miller HH. Preoperative irradiation of primarily unresectable colorectal carcinoma. Cancer 1978;42:1077–81.

    Article  PubMed  CAS  Google Scholar 

  12. Romsdahl MM, Withers HR. Radiotherapy combined with curative surgery: its use as therapy for carcinoma of the sigmoid colon and rectum. Arch Surg 1978;113:446–53.

    PubMed  CAS  Google Scholar 

  13. Roswit B, Higgins GA Jr, Keehn RJ. Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: report of a national Veterans Administration randomized study. Cancer 1975;35:1597–1602.

    Article  PubMed  CAS  Google Scholar 

  14. Stearns MW Jr, Deddish MR, Quan SH, Leaming RH. Preoperative roentgen therapy for cance rof the rectum and rectosigmoid. Surg Gynecol Obstet 1974;138:584–6.

    PubMed  Google Scholar 

  15. Stevens KR Jr, Fletcher WS, Allen CV. Anterior resection and primary anastomosis following high dose preoperative irradiation for adenocarcinoma of the recto-sigmoid. Cancer 1978;41:2065–71.

    Article  PubMed  Google Scholar 

  16. Wassif SB. A pilot study for the evaluation of a new regime of combined therapy for the radical treatment of marginally operable rectal (or colo-rectal) cancer. Eur J Cancer 1974;10:615–9.

    PubMed  CAS  Google Scholar 

  17. Welch CE, Malt RA. Abdominal surgery (second of three parts). N Engl J Med 1979;300:705–12.

    Article  PubMed  CAS  Google Scholar 

  18. Goligher JC, Lee PW, Macfie J, Simpkins KC, Lintott DJ. Experience with the Russian model 249 suture gun for anastomosis of the rectum. Surg Gynecol Obstet 1979;148:517–24.

    Google Scholar 

  19. Schauer RM, Bubrick MP, Feeney DA, et al. Effects of lowdose preoperative irradiation on low anterior anastomosis in dogs. Dis Colon Rectum (in press).

  20. Ellis F. Fractionation in radiotherapy. Mod Trends Radiotherapy 1967;1:34.

    Google Scholar 

  21. Ellis F. The relationship of biologic effect to dose-time fractionnation factors in radiotherapy. Curr Top Radiat Res 1968;4:357–97.

    Google Scholar 

  22. Bubrick MP, Lundeen JW, Hitchcock CR. A comparative radiographic study of low anterior colon anastomoses in dogs. Surgery 1981;89:454–9.

    PubMed  CAS  Google Scholar 

  23. Goligher JC, Graham NG, DeDombal FT. Anastomotic dehiscence after anterior resection of rectum and sigmoid. Br J Surg 1970;57:109–18.

    PubMed  CAS  Google Scholar 

  24. Crowley LG, Anders CJ, Nelsen T, Bagshaw M. Effect of radiation o canine intestinal anastomoses. Arch Surg 1968;96:423–8.

    PubMed  CAS  Google Scholar 

  25. Symonds CJ. Cancer of rectum: excision after application of radium. Proc R Soc Med 1913;7:152.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Hennepin County Medical Center, 701 Park Avenue, 55415, Minneapolis, Minnesota

    Melvin P. Bubrick M.D., Eric S. Rolfsmeyer M.D., Robert M. Schauer M.D. & Claude R. Hitchcock M.D., Ph.D.

  2. Department of Pathology, Hennepin County Medical Center, 701 park Avenue, 55415, Minneapolis, Minnesota

    Robert L. Strom M.D.

  3. the Minneapolis Medical Research Foundation, Minneapolis, Minnesota

    Melvin P. Bubrick M.D., Eric S. Rolfsmeyer M.D., Robert M. Schauer M.D., Robert L. Strom M.D. & Claude R. Hitchcock M.D., Ph.D.

  4. Department of Small Animal Clinical Sciences, University of Minnesota College of Veterinary Medicine, Minneapolis, Minnesota

    Daniel A. Feeney D.V.M. & Gary R. Johnston D.V.M.

Authors
  1. Melvin P. Bubrick M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric S. Rolfsmeyer M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Robert M. Schauer M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel A. Feeney D.V.M.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gary R. Johnston D.V.M.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Robert L. Strom M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Claude R. Hitchcock M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Bubrick, M.P., Rolfsmeyer, E.S., Schauer, R.M. et al. Effects of high-dose and low-dose preoperative irradiation on low anterior anastomoses in dogs. Dis Colon Rectum 25, 406–415 (1982). https://doi.org/10.1007/BF02553643

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02553643

Key words

Search

Navigation