Abstract
Twenty rats with implanted liver tumor were studied. Following baseline angiography, the hepatic artery was embolized with Gelfoam powder or ethanol (n=12) while the controls (n=8) did not undergo embolization. Postmortem Microfil perfusion was performed in all livers. Filling of tumor lakes from the portal vein was seen more often in embolized animals than in controls, indicating the potential role of the portal venous system in the supply of dearterialized hepatic tumors. We discuss the possible clinical implication of our results.
Similar content being viewed by others
References
Breedis C, Young G (1954) Blood supply of neoplasms in the liver. Am J Pathol 30:969–985
Healy JE (1965) Vascular patterns in human metastatic liver tumors. Surgery 120:1187–1193
Rogers W, Edlick RF, Levis DV, Aust JB (1967) Tumor blood flow. I Blood flow in transplantable tumors during growth. Surg Clin N Am 47:1473–1482
Ackerman NB, Hechmer PA (1980) The blood supply of experimental liver metastases. V Increased tumor perfusion with epinephrine. Am J Surg 140:625–631
Soo C-S, Chuang VP, Wallace S, Charnsangavej C, Carrasco H (1983) Treatment of hepatic neoplasm through extrahepatic collaterals. Radiology 147:45–49
Ackerman NB, Lien WM, Kondi ES, Silverman NA (1969) The blood supply of experimental liver metastases. I The distribution of hepatic artery and portal vein blood to “small” and “large” tumor. Surgery 66:1067–1072
Honjo I, Matsumra H (1965) Vascular distribution of hepatic tumors. Experimental study. Rev Int Hepato 15:681–690
Lien WM, Ackerman NB (1970) The blood supply of experimental liver metastases. II A microcirculatory study of the normal and tumor vessels of the liver with the use of perfused silicone rubber. Surgery 68:334–340
Steele G Jr, Sjögren H-O (1974) Cross-reacting tumor associated antigen(s) among chemically induced rat colon carcinomas. Cancer Res 34:1801–1807
Ekelund L, Olin T (1970) Catheterization of arteries in rats. Invest Radiol 5:69–74
Ekelund L, Henrikson H, Olin T, Sjögren H-O (1974) Angiography in hepatic cysts and tumors in the rat. Invest Radiol 9:396–403
Ekelund L, Stigsson L, Jonsson N, Sjögren H-O (1977) Transcatheter arterial embolization of normal liver and experimental hepatic tumors in rats. Acta Radiol [Diagn] 18:641–651
Ackerman NB (1974) The blood supply of experimental liver metastases. IV Changes in vascularity with increasing tumor growth. Surgery 75:589–596
Stigsson L, Ekelund L, Jonsson N, Sjögren H-O (1979) Transcatheter arterial embolization of experimental hepatic tumors in the rat. Acta Radiol [Diagn] 20:422–432
Ackerman NB (1972) Experimental studies on the circulatory dynamics of intrahepatic tumor blood supply. Cancer 29:435–439
Nilsson LAV, Zettergren L (1967) Effect of hepatic artery ligation on induced primary liver carcinoma in rats. Preliminary report. Acta Pathol Microbiol Scand 71:187–193
Lin G, Lunderquist A, Hägerstrand I, Boijsen E (1984) Post-mortem examination of the blood supply and vascular pattern of small liver metastases in man. Surgery (In press)
Honjo I, Suzuki T, Ozawa K, Takasan H, Kitamura O, Ishikawa T (1975) Ligation of a branch of the portal vein for carcinoma of the liver. Am J Surg 130:296–302
Ekelund L, Jonsson N, Lunderquist A (1977) Tumor vessels. Angiographic-histopathologic correlation. Radiologe 17:95–102
Cho KJ, Lunderquist A (1983) Experimental hepatic artery embolization with Gelfoam powder. Invest Radiol 18:189–193
Bookstein JJ, Cho KJ, Davis GB, Dail D (1982) Arterioportal communications. Observations and hypotheses concerning transsinusoidal and transvasal types. Radiology 142:581–590
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ekelund, L., Lin, G. & Jeppsson, B. Blood supply of experimental liver tumors after intraarterial embolization with gelfoam powder and absolute ethanol. Cardiovasc Intervent Radiol 7, 234–239 (1984). https://doi.org/10.1007/BF02553141
Issue Date:
DOI: https://doi.org/10.1007/BF02553141