Abstract
Three cases of perianal Paget's disease are presented. Clinically, three patients had a chronic irritating perianal rash resistant to hydrocortisone cream. One patient had an underlying rectal adenocarcinoma. The controversies in the histogenesis of Paget's cells in perianal Paget's disease remain unresolved, but it appears that perianal Paget's disease probably is more than one disease and is biologically different from mammary Paget's disease.
Similar content being viewed by others
References
Paget J. On disease of the mammary areola preceding cancer of the mammary gland. St Bartholomew Hosp Res London 1874;10:87–9.
Jones RE, Austin C, Ackerman AB. Extramammary Paget's disease: a critical reexamination. Am J Dermatopathol 1979;1:101–32.
Crocker HR. Paget's disease affecting the scrotum and penis. Trans Pathol Soc London 1889;40:187–91.
Langsford G, Kermode D. Perianal Paget's disease: a case report. Aust NZ J Surg 1980;50:181–3.
Kavlie H, Stevenson JK, Gould VE. Perianal Paget's disease. Am Surg 1971;37:485–9.
Darier J, Couillard P. Sur un cas de maladie de Paget de la région perinéo-anale scrotale. Soc Franc Dermatol Syph 1893;4:25–31.
Grow JR, Kshirsagar V, Tolentino M, Gramling J, Schutte AG. Extramammary perianal Paget's disease: report of a case. Dis Colon Rectum 1977;20:436–42.
MacLaughlin WS, Manson RR. Perianal Paget's disease with and without infiltrating carcinoma: report of two cases. Maine Med Assoc 1979;70:149–51.
Subbuswamy SG, Ribeiro BF. Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. Dis Colon Rectum 1981;24:535–8.
Pitman GH, McCarthy JG, Perzin KH, Herter FP. Extrammary Paget's disease. Plast Reconstr Surg 1982;69:238–44.
Secco GB, Lapertosa G, Sertoli MR, Scarpati D, Riboli EB. Perianal Paget's disease: case report of an elderly patient treated with polychemotherapy and radiotherapy. Tumori 1984;70:381–3.
Giltman LI, Osborne PT, Coleman SA, Uthman EO. Paget's disease of the anal mucosa in association with carcinoma demonstrating mucoepidermoid features. J Surg Oncol 1985;28:277–80.
Grodsky L. Extramammary Paget's disease of the perianal region. Dis Colon Rectum 1960;3:502–9.
Arminski TC, Pollard RJ. Paget's disease of the anus secondary to a malignant papillary adenoma of the rectum. Dis Colon Rectum 1973;16:46–55.
Brenden LD, Schwartz RA. Extramammary Paget's disease. Am Fam Physician 1983;28:159–61.
Thin G. Malignant papillary dermatitis of the nipple and the breast tumors with which it is found associated. Br Med J 1881;1:760–3.
Morson BC, Dawson IMP. Extramammary Paget's disease. In: Gastrointestinal pathology. Oxford: Blackwell Scientific Publications, 1979:739–40.
Wood WS, Culling CF. Perianal Paget's disease: histochemical differentiation utilizing the borohydride-KOH-PAS reaction. Arch Pathol 1975;99:442–5.
Helwig EB, Graham JH. Anogenital (extrammary) Paget's disease: a clinicopathological review. Cancer 1963;16:387–403.
Author information
Authors and Affiliations
About this article
Cite this article
Tjandra, J. Perianal Paget's disease. Dis Colon Rectum 31, 462–466 (1988). https://doi.org/10.1007/BF02552618
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02552618