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Interdependence of urinary factors in calcareous bladder stone patients

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Abstract

Twenty-four-hour urinary excretion of calcium, oxalic acid, inorganic phosphorus, magnesium and citric acid was examined in fifty-nine stone formers with bladder stones. Hypercalciuria and hyperoxaluria were present in 18.6% and 44.1%, respectively, while 11.9% of patients had both abnormalities. Hypomagnesuria and hypocitraturia were present in 67.8% and 69.5%, respectively, while 45.7% had both of these abnormalities. Normal urine chemistry in respect of parameters studied was observed only in 1.7% of cases. In 15.2% one risk factor was present, while 83.1% had two or more risk factors. “Path” analysis of the urinary parameters directly related to calcium lithiasis showed that magnesium and oxalic acid have substantial influence on calcium excretion, whereas citric acid had none. The influence of phosphorus did not provide any consistent trend.

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References

  1. Antonacci, A., Colussi, G., DeFerrari, M. E., Lombola, G. Pontoriero, G., Surian, M., Malbert, F., Minetti, L.: Calcium oxalate (CaOx) urine supersaturation in calcium stone formers (CSF). Hypercalciuria versus hyperoxaluria. In: Urolithiasis and Related Clinical Research. Plenum Press, New York-London 1985, p. 283.

    Google Scholar 

  2. Benad, G. W., Weinerth, J. L., Carson, C. C. III: Calcium stone disease: An over review.J. Urol., 135, 1 (1986).

    Google Scholar 

  3. Das, P.: A study of chemical composition of urinary calculi.Indian J. Surg., 39, 144 (1984).

    Google Scholar 

  4. Gindler, E. M., King, J. D.: Rapid colorimetric determination of calcium in biologic fluids with methyl thymol blue,Am. J. Clin. Pathol., 58, 376 (1972).

    PubMed  CAS  Google Scholar 

  5. Hodgkinson, A., Williams, A.: An improved coorimetric procedure for urine oxalate.Clin. Chim. Acta, 36, 127 (1972).

    Article  PubMed  CAS  Google Scholar 

  6. Hodgkinson, A.: Oxalic Acid in Biology and Medicine. Academic Press, London-New Y York-San Francisco 1977.

    Google Scholar 

  7. Hosking, D. H., Wilson, J. W., Liedke, L. H., Smith, L. H., Wilson, D. M.: Urinary citrate excretion in normals and patients with idiopathic calcium urolithiasis. In: Urolithiasis and Related Clinical Research. Plenum Press, New York-London 1985, p. 367.

    Google Scholar 

  8. Jonsson, G.: Magnesium in renal stone disease.Acta Med. Scand., 661 (Suppl.),21 (1982).

    Google Scholar 

  9. Martin, Y., Smith, L. H., Werners, P. G.: Clinical symptoms of 192 urinary stones in Kerala.Indian J. Surg., 39, 144 (1984).

    Google Scholar 

  10. Menon, M., Mahle, C. J.: Oxalate metabolism and renal calculi.J. Urol., 148, 127 (1982).

    Google Scholar 

  11. Natelson, S.: Techniques of Clinical Chemistry. 3rd Ed. Charles C. Thomas, Springfield, Ill. 1971, pp. 491, 576.

    Google Scholar 

  12. Nath, R., Thind, S. K., Murthy, M. S. R., Talwar, H. S., Farooqui, S.: Molecular Aspects of Medicine. Pergamon Press, Oxford-New York 1984.

    Google Scholar 

  13. Pyrah, L. N.: Renal Calculus. Springer-Verlag, Berlin-Heidelberg-New York 1979.

    Google Scholar 

  14. Pendse, A. K., Shrivastava, A. K., Kumawat, J. L., Goyal, A., Ghost, R., Sharma, H. S., Singh, P. P.: Urolithiasis in Udaipur (Rajasthan).J. Indian Med. Assoc., 82, 151 (1984).

    PubMed  CAS  Google Scholar 

  15. Pendse, A. K., Singh, P. P.: The etiology of urolithiasis in Udaipur (Western part of India).Urol. Res., 14, 59 (1986).

    Article  PubMed  CAS  Google Scholar 

  16. Pendse, A. K., Singh, P. P., Rathore, V.: Urinary calculus disease in Jodhpur (North-Western India). I. A prevalence study. In: Multidimensional Approach to Urolithiasis, U.S.O.I., Udaipur, India 1987.

    Google Scholar 

  17. Robertson, W. G., Peacock, M., Heyburn, P. J., Marshall, D. H., Clark, P. B.: Risk factors in calcium stone disease of the urinary tract.Br. J. Urol., 50, 499 (1978).

    Article  Google Scholar 

  18. Rajagopal, G.: A simple colorimetric procedure for estimation of citric acid in urine.Indian J. Exp. Biol., 22, 391 (1984).

    PubMed  CAS  Google Scholar 

  19. Singh, P. P.: Urinary excretion of oxalate in children and adults and the effect of high oxalate diet on the urinary oxalate of adults.Asian Med. J., 19, 44 (1976).

    CAS  Google Scholar 

  20. Singh, P. P., Singh, L. B. K., Prasad, S. N., Singh, M. G.: Urolithiasis in Manipur (North-Eastern region of India). Incidence and chemical composition of stones.Am. J. Clin. Nutr., 31, 1519 (1978).

    PubMed  CAS  Google Scholar 

  21. Singh, P. P., Pendse, A. K., Goyal, A., Ghosh, R., Shrivastava, A. K., Kumawat, J. L.: Blood and urine chemistry of stone formers in local population and evaluation of cystone treatment.Indian Drugs, 27, 264 (1983).

    Google Scholar 

  22. Singh, P. P., Pendse, A. K., Hada, P., Nagori, P. C., Rathore, V., Dashora, P. K.: Sodium is neither a risk nor a protective factor in urolithiasis.Urol. Res., 15, 105 (1987).

    Article  PubMed  CAS  Google Scholar 

  23. Singh, P. P., Pendse, A. K., Punjabi, M., Rathore, V.: Urinary citrate in stone formers. In: Multidimensional Approach to Urolithiasis. U.S.O.I., Udaipur, India 1987.

    Google Scholar 

  24. Silver, J., Rubinger, D., Friendlaender, M. M., Popovtzer, M. M.: Sodium dependent idiopathic hypercalciuria in renal stone formers.Lancet, II, 484 (1983).

    Article  Google Scholar 

  25. Tiselius, H. G., Almgard, L. E., Larsson, L., Sorbo, B.: A biochemical basis for grouping the patients with urolithiasis.Eur. Urol., 4, 241 (1978).

    PubMed  CAS  Google Scholar 

  26. Van Reen, R.: Idiopathic bladder stone disease. Fogarty Foundation, USA 1976.

    Google Scholar 

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Singh, P.P., Pendse, A.K., Rathore, V. et al. Interdependence of urinary factors in calcareous bladder stone patients. International Urology and Nephrology 21, 145–151 (1989). https://doi.org/10.1007/BF02550802

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