Abstract
Twenty-four-hour urinary excretion of calcium, oxalic acid, inorganic phosphorus, magnesium and citric acid was examined in fifty-nine stone formers with bladder stones. Hypercalciuria and hyperoxaluria were present in 18.6% and 44.1%, respectively, while 11.9% of patients had both abnormalities. Hypomagnesuria and hypocitraturia were present in 67.8% and 69.5%, respectively, while 45.7% had both of these abnormalities. Normal urine chemistry in respect of parameters studied was observed only in 1.7% of cases. In 15.2% one risk factor was present, while 83.1% had two or more risk factors. “Path” analysis of the urinary parameters directly related to calcium lithiasis showed that magnesium and oxalic acid have substantial influence on calcium excretion, whereas citric acid had none. The influence of phosphorus did not provide any consistent trend.
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Antonacci, A., Colussi, G., DeFerrari, M. E., Lombola, G. Pontoriero, G., Surian, M., Malbert, F., Minetti, L.: Calcium oxalate (CaOx) urine supersaturation in calcium stone formers (CSF). Hypercalciuria versus hyperoxaluria. In: Urolithiasis and Related Clinical Research. Plenum Press, New York-London 1985, p. 283.
Benad, G. W., Weinerth, J. L., Carson, C. C. III: Calcium stone disease: An over review.J. Urol., 135, 1 (1986).
Das, P.: A study of chemical composition of urinary calculi.Indian J. Surg., 39, 144 (1984).
Gindler, E. M., King, J. D.: Rapid colorimetric determination of calcium in biologic fluids with methyl thymol blue,Am. J. Clin. Pathol., 58, 376 (1972).
Hodgkinson, A., Williams, A.: An improved coorimetric procedure for urine oxalate.Clin. Chim. Acta, 36, 127 (1972).
Hodgkinson, A.: Oxalic Acid in Biology and Medicine. Academic Press, London-New Y York-San Francisco 1977.
Hosking, D. H., Wilson, J. W., Liedke, L. H., Smith, L. H., Wilson, D. M.: Urinary citrate excretion in normals and patients with idiopathic calcium urolithiasis. In: Urolithiasis and Related Clinical Research. Plenum Press, New York-London 1985, p. 367.
Jonsson, G.: Magnesium in renal stone disease.Acta Med. Scand., 661 (Suppl.),21 (1982).
Martin, Y., Smith, L. H., Werners, P. G.: Clinical symptoms of 192 urinary stones in Kerala.Indian J. Surg., 39, 144 (1984).
Menon, M., Mahle, C. J.: Oxalate metabolism and renal calculi.J. Urol., 148, 127 (1982).
Natelson, S.: Techniques of Clinical Chemistry. 3rd Ed. Charles C. Thomas, Springfield, Ill. 1971, pp. 491, 576.
Nath, R., Thind, S. K., Murthy, M. S. R., Talwar, H. S., Farooqui, S.: Molecular Aspects of Medicine. Pergamon Press, Oxford-New York 1984.
Pyrah, L. N.: Renal Calculus. Springer-Verlag, Berlin-Heidelberg-New York 1979.
Pendse, A. K., Shrivastava, A. K., Kumawat, J. L., Goyal, A., Ghost, R., Sharma, H. S., Singh, P. P.: Urolithiasis in Udaipur (Rajasthan).J. Indian Med. Assoc., 82, 151 (1984).
Pendse, A. K., Singh, P. P.: The etiology of urolithiasis in Udaipur (Western part of India).Urol. Res., 14, 59 (1986).
Pendse, A. K., Singh, P. P., Rathore, V.: Urinary calculus disease in Jodhpur (North-Western India). I. A prevalence study. In: Multidimensional Approach to Urolithiasis, U.S.O.I., Udaipur, India 1987.
Robertson, W. G., Peacock, M., Heyburn, P. J., Marshall, D. H., Clark, P. B.: Risk factors in calcium stone disease of the urinary tract.Br. J. Urol., 50, 499 (1978).
Rajagopal, G.: A simple colorimetric procedure for estimation of citric acid in urine.Indian J. Exp. Biol., 22, 391 (1984).
Singh, P. P.: Urinary excretion of oxalate in children and adults and the effect of high oxalate diet on the urinary oxalate of adults.Asian Med. J., 19, 44 (1976).
Singh, P. P., Singh, L. B. K., Prasad, S. N., Singh, M. G.: Urolithiasis in Manipur (North-Eastern region of India). Incidence and chemical composition of stones.Am. J. Clin. Nutr., 31, 1519 (1978).
Singh, P. P., Pendse, A. K., Goyal, A., Ghosh, R., Shrivastava, A. K., Kumawat, J. L.: Blood and urine chemistry of stone formers in local population and evaluation of cystone treatment.Indian Drugs, 27, 264 (1983).
Singh, P. P., Pendse, A. K., Hada, P., Nagori, P. C., Rathore, V., Dashora, P. K.: Sodium is neither a risk nor a protective factor in urolithiasis.Urol. Res., 15, 105 (1987).
Singh, P. P., Pendse, A. K., Punjabi, M., Rathore, V.: Urinary citrate in stone formers. In: Multidimensional Approach to Urolithiasis. U.S.O.I., Udaipur, India 1987.
Silver, J., Rubinger, D., Friendlaender, M. M., Popovtzer, M. M.: Sodium dependent idiopathic hypercalciuria in renal stone formers.Lancet, II, 484 (1983).
Tiselius, H. G., Almgard, L. E., Larsson, L., Sorbo, B.: A biochemical basis for grouping the patients with urolithiasis.Eur. Urol., 4, 241 (1978).
Van Reen, R.: Idiopathic bladder stone disease. Fogarty Foundation, USA 1976.
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Singh, P.P., Pendse, A.K., Rathore, V. et al. Interdependence of urinary factors in calcareous bladder stone patients. International Urology and Nephrology 21, 145–151 (1989). https://doi.org/10.1007/BF02550802
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DOI: https://doi.org/10.1007/BF02550802