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Long-term effects of steroid and cytostatic treatment on the clinical course of idiopathic membranous glomerulonephritis

Retrospective study

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Abstract

The clinical course of 30 patients with idiopathic membranous glomerulonephritis has been followed up for 8.1±3.4 (4–17) years. First, in each case a long-term prednisone treatment was administered. During this therapy 12 (40%) patients improved and 9 had remission. In the 18 (60%) steroid resistant cases the treatment was combined with cytostatic drugs. After a combined regime for 1.9±0.8 years, 8 patients have improved, 2 of whom remitted.

It has been suggested that due to a long-term immunomodulator therapy the level of urinary protein excretion might be reduced in 77% of patients. There was no effect of the applied treatment in 7% of cases, still in 16% a gradual deterioration was observed. Relapsing nephrotic syndrome has occurred in 3 (10%) of the total cases. Side effects requiring cessation of treatment were not observed.

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Authors and Affiliations

  1. First Department of Internal Medicine, Szeged University Medical School, Szeged, Hungary

    G. Mohácsi & S. Sonkodi

  2. Department of Pathology, Szeged University Medical School, Szeged, Hungary

    A. Magori

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  1. G. Mohácsi
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  2. A. Magori
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  3. S. Sonkodi
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Mohácsi, G., Magori, A. & Sonkodi, S. Long-term effects of steroid and cytostatic treatment on the clinical course of idiopathic membranous glomerulonephritis. International Urology and Nephrology 20, 315–325 (1988). https://doi.org/10.1007/BF02549523

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  • DOI: https://doi.org/10.1007/BF02549523

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