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A new method for calculating the accretion rate of bone calcium and some observations on the suitability of strontium-85 as a tracer for bone calcium

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Abstract

  1. 1.

    A new method for calculating the accretion rate (A) of bone calcium is proposed, based on an impulse analysis of47Ca data. The method is free of most of the assumptions inherent in previous methods of analysis and appears to give more accurate estimates.

  2. 2.

    In fourteen normal subjects and twelve patients with metabolic bone disease, measurements ofA by the new method gave very similar results to the mineralization rate calculated by the method of Burkinshawet al. (1969). Analysis of twelve studies performed by Neeret al. (1967) gave good agreement with their five compartment model. A close relation betweenA and Marshall’s (1964)A 5 was observed, but the latter gave systematically higher results.

  3. 3.

    In sixteen studies both47Ca and85Sr were injected simultaneously. Although there were no systematic differences between the values ofA for the two tracers, the differences between individual values were greater than the known experimental errors.

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  1. Radioisotopes Division, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, England

    J. Reeve, R. Wootton & R. Hesp

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Reeve, J., Wootton, R. & Hesp, R. A new method for calculating the accretion rate of bone calcium and some observations on the suitability of strontium-85 as a tracer for bone calcium. Calc. Tis Res. 20, 121–135 (1976). https://doi.org/10.1007/BF02546402

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