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Effect of essential fatty acid deficiency on myelin proteins

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Lipids

Abstract

The effect of essential fatty acid (EFA) deficiency on rat-brain myelin proteins was studied. Rats were maintained on a lipid-free diet and compared with control rats fed the same diet supplemented with 3% corn oil. At 17 days of age, each pup was injected with [3H]leucine and rats from each group were killed over a period of 163 days. Although a large decrease occurred in the total amount of myelin protein per brain, the proportions of constituent myelin proteins remained relatively unchanged. Metabolic studies showed a decrease in the net turnover of myelin proteins analogous to that previously demonstrated for myelin phospholipid (PL).

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Abbreviations

EFA:

essential fatty acid

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Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 36th Street and Spruce, 19104, Philadelphia, PA

    Sheldon L. Miller, David M. Klurfeld, Bernadette Loftus & David Kritchevsky

Authors
  1. Sheldon L. Miller
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  2. David M. Klurfeld
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  3. Bernadette Loftus
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  4. David Kritchevsky
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Miller, S.L., Klurfeld, D.M., Loftus, B. et al. Effect of essential fatty acid deficiency on myelin proteins. Lipids 19, 478–480 (1984). https://doi.org/10.1007/BF02537414

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  • DOI: https://doi.org/10.1007/BF02537414

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