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Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin

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Lipids

Abstract

The present study demonstrated that nitric oxide, which is an important mammalian metabolite, can inhibit oxidation by lipoxygenase, cyclooxygenase and hemoglobin. The inhibition is manifested as a lag-phase that is reversible. The inhibitory effect of nitric oxide on lipoxygenase and cyclooxygenase seems to derive from i) the capability of ·NO to reduce the ferric enzyme to the ferrous form, which is inactive; ii) competition for the iron site available for exogenous ligands; and iii) the radical scavenging ability of the nitroxide radical. Nitric oxide may act as a modulator of the arachidonic acid cascade and in the generation of oxygen-active species.

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Abbreviations

cGMP:

cyclic guanidine monophosphate

Cyclo:

cyclooxygenase

DETA:

diethylenetriaminepentaacetic acid

Hb:

hemoglobin

LPO:

lipoxygenase

·NO:

nitric oxide

·NO-Cyclo:

nitric oxide cyclooxygenase

·NO-Hb:

nitric oxide hemoglobin

·NO-LPO:

nitric oxide lipoxygenase

TXA2 :

thromboxane A2

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Authors and Affiliations

  1. Department of Food Science, Agricultural Research Organization, The Volcani Center, P.O. Box 6, 50250, Bet Dagan, Israel

    Joseph Kanner, Stela Harel & Rina Granit

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  1. Joseph Kanner
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  2. Stela Harel
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  3. Rina Granit
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Kanner, J., Harel, S. & Granit, R. Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin. Lipids 27, 46–49 (1992). https://doi.org/10.1007/BF02537058

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  • DOI: https://doi.org/10.1007/BF02537058

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