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Hypoxia, PAF, and necrotizing enterocolitis

  • PAF and the Gastrointestinal System
  • Review
  • Published:
Lipids

Abstract

Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.

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Abbreviations

ABG:

arterial blood gas

BE:

base excess

LPS:

bacterial endotoxin (lipopolysaccharide)

NEC:

necrotizing enterocolitis

PAF:

platelet-activating factor

TNF:

tumor necrosis factor

WBC:

white blood cells

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Author information

Author notes

  1. Michael S. Caplan

    Present address: Department of Pediatrics, Evanston Hospital, 2650 Ridge Avenue, 60201, Evanston, IL

Authors and Affiliations

  1. Departments of Pediatrics and Pathology, Children's Memorial Hospital, Northwestern University Medical School, 60614, Chicago, Illinois

    Michael S. Caplan, Xiao-Ming Sun & Wei Hsueh

Authors
  1. Michael S. Caplan
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  2. Xiao-Ming Sun
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  3. Wei Hsueh
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Cite this article

Caplan, M.S., Sun, XM. & Hsueh, W. Hypoxia, PAF, and necrotizing enterocolitis. Lipids 26, 1340–1343 (1991). https://doi.org/10.1007/BF02536562

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  • DOI: https://doi.org/10.1007/BF02536562

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