Abstract
We have previously reported that certain fetal tissues including the lung and kidney have an increased platelet-activating factor (PAF) content and enzymatic mechanism for its elevated biosynthesis during the latter stages of pregnancy. In contrast, in the maternal plasma compartment of both the rabbit and human, a decreased capacity to inactivate PAF has been demonstrated. The PAF acetylhydrolase in the fetal plasma is also suppressed. The present study was undertaken to determine the mechanism(s) involved in the regulation of PAF acetylhydrolase. The 17α-ethynylestradiol was administered (intraperitoneal [i.p.] 2.5 mg/kg body wt 5 days) to female and male rats. The plasma PAF acetylhydrolase activity decreased 5-fold. A decrease was observed when a concentration of the estrogen as low as 50 μg/kg was employed. The injection of dexamethasone (i.p., 1.3 mg/kg body wt, 5 days) to male and female rats resulted in a 3-fold increase in the plasma PAF acetylhydrolase activity. The activity returned to the values prior to hormone treatment 4 days after cessation of treatment. Testosterone and progesterone were without effect on plasma acetylhydrolase activity. The change in PAF acetylhydrolase activity caused by estrogen and the glucocorticoid was reflected by a change in the activity in the HDL fraction and not due to the presence of an inhibitor or activator in the plasma of the hormone-treated animals. Human serum obtained from a group of women, in which the 17β-estradiol concentration was elevated in preparation for anin vitro fertilization procedure, showed an inverse relationship between the plasma estrogen concentration and the PAF acetylhydrolase activity. It is suggested that estrogen is responsible for the regulation of PAF acetylhydrolase and the decrease in the plasma PAF acetylhydrolase during the latter stages of pregnancy in both the maternal and fetal plasma caused by the hyperestrogenic state that occurs during this period. The observed increase in PAF acetylhydrolase by dexamethasone may account for, in part, the known anti-inflammatory properties of this steroid by decreasing the concentration of this potent autacoid.
Similar content being viewed by others
Abbreviations
- PAF:
-
platelet-activating factor
References
Benveniste, J., Henson, P.M., and Cochran, C.C.G. (1972)J. Exp. Med. 136, 1356–1377.
Demopoulos, C.A., Pinckard, R.N., and Hanahan, D.J. (1979)J. Biol. Chem. 154, 9355–9358.
Benveniste, J., Tence, M., Varenne, P., Bidault, J., Boullet, C., and Polonsky, J. (1979)C.R.C. Acad. Sci. Paris. (ser. D) 289, 1037–1040.
Blank, M.L., Snyder, F., Byers, L.W., Brooks, B., and Muirhead, E.E. (1979)Biochem. Biophys. Res. Commun. 90, 1194–1200.
Hanahan, D.J. (1986)Ann. Rev. Biochem. 55, 483–509.
Braquet, P., Touqui, L., Shen, T.Y., and Vargaftig, T.B. (1987)Pharmacol. Rev. 39, 97–145.
Snyder, F. (1989)Proc. Soc. Exp. Biol. Med. 190, 125–135.
O'Flaherty, J.T., Wykle, R.L., Miller, C.H., Lewis, J.C., Waite, M., Bass, D.A., McCall, C.E., and DeChatelet, L.R. (1981)Am. J. Pathol. 103, 70–78.
Wardlow, A.J., Moqbel, R., Cromwell, O., and Kay, A.B. (1986)J. Clin. Invest. 78, 1701–1706.
Tamura, N., Agrawal, D.K., Suliaman, F.A., and Townley, R.G. (1987)Biochem. Biophys. Res. Commun. 142, 638–644.
Humphrey, D.M., Hanahan, D.J., and Pinckard, R.N. (1982)Lab. Invest. 47, 227–234.
Humphrey, D.M., McManus, L.M., Satouchi, K., Hanahan, D.J., and Pinckard, R.N. (1982)Lab. Invest. 46, 422–427.
Humphrey, D.M., McManus, L.M., Hanahan, D.J., and Pinckard, R.N. (1984)Lab. Invest. 50, 16–25.
O'Neill, C. (1984) inPlatelet-Activating Factor and Human Diseases (Barnes, P.J., Page, C.P., and Henson, P.M., eds.) Blackwell Scientific Publications, Oxford, United Kingdom, pp. 282–296.
Johnston, J.M., and Maki, N. (1989) inPlatelet-Activating Factor and Human Diseases (Barnes, P.J., Page, C.P., and Henson, P.M., eds.) Blackwell Scientific Publications, Oxford, United Kingdom, pp. 297–323.
Abisogun, A.O., Braquet, P., and Tsafriri, A. (1989)Science 243, 381–383.
Kumar, R., Harper, M.J.K., and Hanahan, D. (1988)Arch. Biochem. Biophys. 260, 497–502.
Lee, T.-C., and Snyder, F. (1989) inPlatelet-Activating Factor and Human Diseases (Barnes, P.J., Page, C.P., and Henson, P.M., eds.) Blackwell Scientific Publications, Oxford, United Kingdom, pp. 1–22.
Lenihan, D.J., Greenberg, N., and Lee, T.-C. (1985)Comp. Biochem. Physiol. 81C, 81–86.
Suzuki, Y., Miwa, M., Harada, M., and Matsumoto, M. (1988)Eur. J. Biochem. 712, 117–120.
Satoh, K., Imaizumi, T.-A., Kawamura, Y., Yoshida, H., Takamatsu, S., and Mizono, S. (1988)Prostaglandins 35, 685–698.
Maki, N., Hoffman, D.R., and Johnston, J.M. (1988)Proc. Natl. Acad. Sci. USA 85, 728–732.
Johnston, J.M. (1989) inPlatelet-Activating Factor and Diseases (Saito, K., and Hanahan, D.J., eds.) International Medical Publishers, Tokyo, Japan, pp. 129–152.
Miwa, M., Miyake, T., Yamanaka, T., Sugatani, J., Suzuki, Y., Sakata, S., Araki, Y., and Matsumoto, M. (1988)J. Clin. Invest. 82, 1983–1991.
Hofmann, B., Ruhling, K., Spangenberg, P., and Ostermann, G. (1989)Haemostasis 19, 180–184.
Blank, M.L., Hall, M.N., Cress, E.A., and Snyder, F. (1983)Biochem. Biophys. Res. Commun. 113, 666–671.
Crook, J.E., Mroczkowski, P.J., Cress, E.A., Blank, M.L., and Snyder, F. (1988)Clin. Sci. 74, 393–396.
Elstad, M.R., Stafforini, D.M., Stremler, K.E., Zimmerman, G.A., McIntyre, M., and Prescott, S.M. (1989) inPlatelet-Activating Factor and Diseases (Saito, K., and Hanahan, D.J., eds.) International Medical Publishers, Tokyo, Japan, pp. 29–84.
Havel, R.J., Eber, H.A., and Bragdom, J.H. (1955)J. Clin. Invest. 34, 1345–1353.
Pritchard, P.H. (1987)Biochem. J. 246, 791–794.
Blank, M.L., Lee, T.-C., Fitzgerald, V., and Snyder, F. (1981)J. Biol. Chem. 251, 175–178.
Farr, R.S., Cox, C.P., Wardlow, M.L., and Jorgensen, R. (1980)Clin. Immunol. Immunopathol. 15, 318–330.
Farr, R.S., Wardlow, M.L., Cox, C.P., Meng, K.E., and Greene, D.E. (1983)Fed. Proc. 42, 3120–3122.
Harper, M.J.K. (1989)Biol. Reprod. 40, 907–913.
Billah, M.M., and Johnston, J.M. (1983)Biochem. Biophys. Res. Commun. 113, 51–58.
Nishihara, J., Ishibashi, T., Imai, Y., and Muramatsu, T. (1984)Lipids 19, 907–910.
Hoffman, D.R., Romero, R., and Johnston, J.M. (1990)Am. J. Obstet. Gynecol. 162, 525–528.
Hoffman, D.R., Truong, C.T., and Johnston, J.M. (1986)Biochim. Biophys. Acta 879, 88–96.
Billah, M.M., Di Renzo, G.C., Ban, C., Truong, C.T., Hoffman, D.R., Anceschi, M.M., Bleasdale, J.E., and Johnston, J.M. (1985)Prostaglandins 30, 841–850.
Bleasdale, J.E., Bala, G.A., Thakur, N.R., McGuire, J.C., and Di Renzo, G.C. (1989) inProceedings of XI European Congress of Perinatal Medicine, Harwood Academic Publishers, Switzerland, pp. 828–834.
Montrucchio, G., Alloatti, G., Tetta, C., Roffinello, C., Emanuelli, G., and Camussi, G. (1986)Prostaglandins 32, 539–554.
Tetta, G., Montrucchio, G., Alloatti, G., Roffinello, C., Emanuellelli, G., Benedetto, C., Camussi, G., and Massobrio, M. (1986)Proc. Soc. Exp. Biol. Med. 183, 376–381.
Zhu, Y.-P., Word, R.A., and Johnston, J.M. (1990)Proc. Soc. Gynecol. Invest., abstract, No. 130, p. 161.
Zhu, Y.-P., Hoffman, D.R., Hwang, S.-B., Miyaura, S., and Johnston, J.M. (1991)Biol. Reprod. 44, 39–42.
Angle, M.J., Pinckard, R.N., Showell, H.J., and McManus, L.M. (1987)Lab. Invest. 57, 321–328.
Author information
Authors and Affiliations
About this article
Cite this article
Miyaura, S., Maki, N., Byrd, W. et al. The hormonal regulation of platelet-activating factor acetylhydrolase activity in plasma. Lipids 26, 1015–1020 (1991). https://doi.org/10.1007/BF02536494
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02536494