Skip to main content
SpringerLink
Log in

Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats

  • Papers from the Brian L. Walker Memorial Symposium on Lipids and Cancer Presented at the 76th AOCS Annual Meeting in Philadelphia, Pennsylvania, May 1985
  • Published:
Lipids

Abstract

High fat diets promote the development of mammary tumors induced in rats by 7,12-dimethylbenz(a)anthracene (DMBA), and polyunsaturated fats are more effective than saturated fats. This difference is related to the linoleic acid content of polyunsaturated vegetable oils, but the amount of linolealte required for maximum tumor promotion appears to be higher than indicated by earlier experiments. Comparison of the effects of a polyunsaturated vegetable oil (corn oil) containing linoleate with a fish oilo (menhaden oil) containing polyunsaturated fatty acids derived from linolenic acid showed that higher dietary mammary tumors, while corresponding levels of menhaden oil had an inhibitory effect. This is further evidence that promotion of mammary tumorigenesis by polyunsaturated vegetable oils may be mediated by prostaglandins or other biologically active eicosanoids derived from n−6 fatty acids.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gammal, E.B., Carroll, K.K., and Plunkett, E.R. (1967)Cancer Res. 27, 1737–1742.

    PubMed  CAS  Google Scholar 

  2. Carroll, K.K., and Khor, H.T. (1971)Lipids 6, 415–420.

    Article  PubMed  CAS  Google Scholar 

  3. Hopkins, G.J., and Carroll, K.K. (1979)JNCI 62, 1009–1012.

    PubMed  CAS  Google Scholar 

  4. Hopkins, G.J., Kennedy, T.G., and Carroll, K.K. (1981)JNCI 66, 517–522.

    PubMed  CAS  Google Scholar 

  5. Rao, G.A., and Abraham, S. (1977)J. Natl. Cancer Inst. 58, 445–447.

    PubMed  CAS  Google Scholar 

  6. Hillyard, L.A., and Abraham, S. (1979)Cancer Res. 39, 4430–4437.

    PubMed  CAS  Google Scholar 

  7. Carter, C.A., Milholland, R.J., Shea, W., and Ip, M.M. (1983)Cancer Res. 43, 3559–3562.

    PubMed  CAS  Google Scholar 

  8. Kollmorgen, G.M., King, M.M., Kosanke, S.D., and Do, C. (1983)Cancer Res. 43, 4714–4719.

    PubMed  CAS  Google Scholar 

  9. Oliw, E., Granström, E., and Änggård, E. (1983) inNew Comprehensive Biochemistry, Vol. 5. Prostaglandins and Related Substances (Pace-Asciak, C., and Granström, E., eds.) pp. 1–44, Elsevier, Amsterdam.

    Google Scholar 

  10. Kalamegham, R., and Carroll, K.K. (1984)Nutr. Cancer 6, 22–31.

    Article  PubMed  CAS  Google Scholar 

  11. Tinsley, I.J., Schmitz, J.A., and Pierce, D.A. (1981)Cancer Res. 41, 1460–1465.

    PubMed  CAS  Google Scholar 

  12. Chan, P-C., Ferguson, K.A., and Dao, T.L. (1983)Cancer Res. 43, 1079–1083.

    PubMed  CAS  Google Scholar 

  13. McCay, P.B., King, M.M., and Pitha, J.V. (1981)Cancer Res. 41, 3745–3748.

    PubMed  CAS  Google Scholar 

  14. Ip, C., Carter, C.A., andIp, M.M. (1985)Cancer Res. 45, 1997–2001.

    PubMed  CAS  Google Scholar 

  15. Jurkowski, J.J., and Cave, W.T. Jr. (1984)Proc. Am. Assoc. Cancer Res. 25, 210.

    Google Scholar 

  16. Karmali, R.A., Marsh, J., and Fuchs, C. (1984)JNCI 73, 457–461.

    PubMed  CAS  Google Scholar 

  17. Gabor, H., and Abraham, S. (1985)Proc. Am. Assoc. Cancer Res. 26, 126.

    Google Scholar 

  18. O'Connor, T.P., Roebuck, B.D., Peterson, F., and Campbell, T.C. (1985)Fed. Proc. 44, 769.

    Google Scholar 

  19. Flower, R.J. (1979) inOxygen Free Radicals and Tissue Damage, Ciba Foundation Symposium 65, pp. 121–138, Excerpta Medica, Amsterdam.

    Google Scholar 

  20. Bird, R.P., Draper, H.H. and Valli, V.E.O. (1982)J. Toxicol. Environ. Health 10, 897–905.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Kenneth K. Carroll (Career Investigator)

    Present address: Medical Research Council of Canada, Canada

Authors and Affiliations

  1. Department of Biochemistry, University of Western Ontario, N6A 5C1, London, Ontario, Canada

    Laura M. Braden & Kenneth K. Carroll (Career Investigator)

Authors
  1. Laura M. Braden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenneth K. Carroll
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Braden, L.M., Carroll, K.K. Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids 21, 285–288 (1986). https://doi.org/10.1007/BF02536414

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02536414

Keywords

Search

Navigation