Skip to main content
SpringerLink
Log in

Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil

  • Articles
  • Published:
Lipids

Abstract

The metabolism of α-linolenic acid from canola oil was studied in eight normolipidemic men. The 42-day study was divided into three periods: a 6-day pre-experimental and two 18-day experimental. Approximately 75% of the dietary fat (28% of total energy) was provided by a mixture of fats during the pre-experimental period and either canola oil (CO) or sunflower oil (SO) during the experimental periods. The CO and SO diets were fed in a cross-over design. The ratios of linoleic to linolenic acid were 2.6∶1 and 73.9∶1 in the CO and SO diets, respectively. Dietary fat source had an effect on plasma phospholipid fatty acids: 18∶1n−9, 18∶3n−3 and 20∶5n−3 were higher (p<0.05), and 18∶2n−6 was lower in the phosphatidylcholine fraction; 18∶1n−9 was higher and 20∶4n−6 lower in the phosphatidyl-ethanolamine fraction; and 18∶1n−9 and 20∶5n−3 were higher and 20∶4n−6 and 22∶6n−3 were lower in the alkenylacyl-ethanolamine phospholipid fraction on the CO diet as compared to the SO diet. Consumption of the canola oil diet resulted in higher n−3 fatty acid levels and lower n−6 fatty acid levels in plasma phospholipids than consumption of the sunflower oil diet.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

AA:

arachidonic acid

CAN-SUN:

canola-sunflower group

CO:

canola oil

EPA:

eicosapentaenoic acid

LA:

linoleic acid

LNA:

α-linolenic acid

OA:

oleic acid

PC:

phosphatidylcholine

PE:

phosphatidylethanolamine

PPE:

alkenylacyl ethanolamine phospholipid

PPP:

platelet poor plasma

SO:

sunflower oil

SUNCAN:

sunflower-canola group

TLC:

thin-layer chromatography

References

  1. Dyerberg, J. (1981)Phil. Trans. Royal Soc. London 294, 373–381.

    CAS  Google Scholar 

  2. Weiner, B.H., Ockene, I.S., Levine, P.H., Cuenoud, H.F., Fisher, M., Johnson, B.F., Daoud, A.S., Jarmolych, J., Hosmer, D., Johnson, M.H., Natale, A., Vaudreuil, C., and Hoogasian, J.J. (1986)New Engl. J. Med. 315, 841–846.

    Article  PubMed  CAS  Google Scholar 

  3. Herold, P.M., and Kinsella, J.E. (1986)Am. J. Clin. Nutr. 43, 566–598.

    PubMed  CAS  Google Scholar 

  4. Kinsella, J.E. (1988)Food Technol. 42(10), 124–145.

    CAS  Google Scholar 

  5. Dyerberg, J. (1986)Nutr. Rev. 44, 125–134.

    Article  PubMed  CAS  Google Scholar 

  6. Sanders, T.A.B., and Younger, K.M. (1981)Br. J. Nutr. 45, 613–616.

    Article  PubMed  CAS  Google Scholar 

  7. Lasserre, M., Mendy, F., Spielmann, D., and Jacotot, B.Lipids 20, 227–233.

  8. Renaud, S., Godsey, F., Dumont, E., Thevenon, C., Ortchanian, E., and Martin, J.L. (1986)Am. J. Clin. Nutr. 43, 136–150.

    PubMed  CAS  Google Scholar 

  9. Renaud, S., Morazain, R., Godsey, F., Dumont, E., Thevenon, C., Martin, J.L., and Mendy, F. (1986)Atherosclerosis 60, 37–48.

    Article  PubMed  CAS  Google Scholar 

  10. Holub, B.J., Celi, B., and Skeaff, C.M. (1988)Throm. Res. 50, 135–143.

    Article  CAS  Google Scholar 

  11. McDonald, B.E., Gerrard, J.M., Bruce, V.M., and Corner, E.J. (1989)Am. J. Clin. Nutr. 50, 1382–1388.

    PubMed  CAS  Google Scholar 

  12. Folch, J., Lees, M., and Sloane Stanley, G.H. (1957)J. Biol. Chem. 226, 497–509.

    PubMed  CAS  Google Scholar 

  13. Aukema, H.M., and Holub, B.J. (1988) inDietary ω3 and ω6 Fatty Acids: Biological Effects and Nutritional Essentiality (Galli, C. and Simopoulos, A.P., eds.) pp. 81–90, Plenum Press, New York.

    Google Scholar 

  14. Holub, B.J., and Skeaff, C.M. (1987)Methods Enzymol. 141 234–244.

    Article  PubMed  CAS  Google Scholar 

  15. Weiner, T.W., and Sprecher, H. (1984)Biochim. Biophys. Acta 79, 293–303.

    Google Scholar 

  16. Adam, O., Wolfram, G., and Zöllner, N. (1986)J. Lipid Res. 27, 421–426.

    PubMed  CAS  Google Scholar 

  17. Weaver, B.J., Corner, E.J., Bruce, V.M., McDonald, B.E., and Holub, B.J. (1990)Am. J. Clin. Nutr. 51, 594–598.

    PubMed  CAS  Google Scholar 

  18. Mest, H.-J., Beitz, J., Heinroth, I., Block, H.-U., and Forster, W. (1983)Klin. Wochenschr. 61, 187–191.

    Article  PubMed  CAS  Google Scholar 

  19. Mead, J.F., Alfin-Slater, R.B., Howton, D.R., and Popjak, G. (1986)Lipids: Chemistry, Biochemistry and Nutrition, pp. 139–145, Plenum Press, New York.

    Google Scholar 

  20. Budowski, P., Trostler, N., Lupo, M., Vaisman, N., and Eldor, A. (1984)Nutr. Res. 4, 343–346

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Foods and Nutrition, University of Manitoba, R3T 2N2, Winnipeg, Canada

    Elizabeth J. Corner, Vivian M. Bruce & Bruce E. McDonald

Authors
  1. Elizabeth J. Corner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vivian M. Bruce
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bruce E. McDonald
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Corner, E.J., Bruce, V.M. & McDonald, B.E. Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil. Lipids 25, 598–601 (1990). https://doi.org/10.1007/BF02536008

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02536008

Keywords

Search

Navigation