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Effect of ethanol administration on fatty acid desaturation

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Lipids

Abstract

The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The Δ6 and Δ5 desaturases were inhibited by ethanol whereas the Δ9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of Δ6 and Δ5 desaturases by ethanol.

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Author notes

  1. Anibal Mario Nervi (Member), Raul Omar Peluffo (Member) & Rodolfo R. Brenner (Member)

    Present address: the Carrera del investigador Cientifico of the Consejo Nacional de Investigaciones Cientifica y Técnicas, Argentina

Authors and Affiliations

  1. Catedra de Bioquimica, Instituto de Fisiología, Faculad de Ciencias Médicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900-La, Plata, Argentina

    Anibal Mario Nervi (Member), Raul Omar Peluffo (Member), Rodolfo R. Brenner (Member) & Alicia Isabel Leikin

Authors
  1. Anibal Mario Nervi
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  2. Raul Omar Peluffo
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  3. Rodolfo R. Brenner
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  4. Alicia Isabel Leikin
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Nervi, A.M., Peluffo, R.O., Brenner, R.R. et al. Effect of ethanol administration on fatty acid desaturation. Lipids 15, 263–268 (1980). https://doi.org/10.1007/BF02535837

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  • DOI: https://doi.org/10.1007/BF02535837

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