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The role of neutral glycolipids and phospholipids in myxovirus-induced membrane fusion

  • Symposium: Immunological Activities of Membranous Systems Held at the AOCS Annual Meeting in Toronto, Canada , May 2–6, 1982
  • Published:
Lipids

Abstract

Myxoviruses (influenza virus and paramyxovirus) enter host cells by two successive steps consisting of attachment and fusion between viral and cellular membranes. The initial attachment is known to occur through specific binding of the viruses with the neuraminic acid-containing receptors of cellular membranes. Evidence is presented here that, in the following step of membrane fusion, neutral glycolipids terminating in galactose and certain phospholipids (primarily lecithin and sphingomyelin) interact with the viral envelopes and that this interaction may be fundamental to the fusion process.

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Authors and Affiliations

  1. Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, 1000, Berlin-33, Germany

    Richard T. C. Huang

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  1. Richard T. C. Huang
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Huang, R.T.C. The role of neutral glycolipids and phospholipids in myxovirus-induced membrane fusion. Lipids 18, 489–492 (1983). https://doi.org/10.1007/BF02535790

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  • DOI: https://doi.org/10.1007/BF02535790

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