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Geraniol interferes with membrane functions in strains ofCandida andSaccharomyces

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Lipids

Abstract

Geraniol, an olefinic terpene, was found to inhibit growth ofCandida albicans andSaccharomyces cerevisiae strains. Geraniol was shown to enhance the rate of potassium leakage out of whole cells and also was shown by fluorescence polarization to increaseC. albicans membrane fluidity. Biophysical studies using differential scanning calorimetry, fluorescence polarization and osmotic swelling of phospholipid vesicles demonstrated that geraniol decreased the phase-transition temperature of dipalmitoylphosphatidylcholine vesicles, affected fluidity throughout the bilayer, particularly the central portion of the bilayers, and caused an increase in bilayer permeability to erythritol. Geraniol may have potential use as an antifungal agent.

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Abbreviations

AS:

anthracene stearic acid

DPH:

1,6-diphenyl-1,3,5-hexatriene

DPPC:

dipalmitoylphosphatidylcholine

MIC:

minimum inhibitory concentration

MLV:

multilamellar vesicles

P:

polarization

TMA-DPH:

1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene

YPD:

yeast-complete medium

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Authors and Affiliations

  1. Department of Biology, Indiana University-Purdue University at Indianapolis, 1125 East 38th St., P.O. Box 647, 45223, Indianapolis, IN

    Martin Bard, Mark R. Albrecht, Navyash Gupta, Cynthia J. Guynn & William Stillwell

Authors
  1. Martin Bard
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  2. Mark R. Albrecht
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  3. Navyash Gupta
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  4. Cynthia J. Guynn
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  5. William Stillwell
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Bard, M., Albrecht, M.R., Gupta, N. et al. Geraniol interferes with membrane functions in strains ofCandida andSaccharomyces . Lipids 23, 534–538 (1988). https://doi.org/10.1007/BF02535593

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  • DOI: https://doi.org/10.1007/BF02535593

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