Skip to main content
SpringerLink
Log in

Effect of dietary fat on individual long-chain fatty acyl-CoA esters in rat liver and skeletal muscle

  • Communications
  • Published:
Lipids

Abstract

The effect of dietary fat on the long-chain acyl-CoA ester profile of liver and skeletal muscle was investigated by feeding weanling rats 12%-fat diets composed of high-linoleic safflower oil (73% 18∶2n−6), high-oleic safflower oil (70% 18∶1n−9) or olive oil (70% 18∶1n−9) for six and ten weeks. Approximately 50% of both hepatic and skeletal muscle acyl-CoA esters comprised linoleoyl-CoA or oleoyl-CoA with high-linoleic or oleic feeding, respectively. Total hepatic acyl-CoA ester concentration was 40% higher (p<0.05) in rats fed 12% fat compared with controls fed a 4%-fat diet. These data demonstrate that the long-chain acyl-CoA ester profile of liver and skeletal muscle reflects the dietary fatty acid profile.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ANOVA:

analysis of variance

GLM:

general linear model

HPLC:

high performance liquid chromatography

References

  1. Woldegiorgis, G., Yousufzai, S.Y.K., and Shrago, E. (1982)J. Biol. Chem. 257, 14783–14787.

    PubMed  CAS  Google Scholar 

  2. Powell, G.W., Tippett, P.S., Kiorpes, T.C., McMillin-Wood, J., Call, K.E., Schulz, H., Tanaka, K., Kang, E.S., and Shrago, E. (1985)Fed. Proc. 44, 81–84.

    Google Scholar 

  3. Stubbs, C.D., and Smith, A.D. (1984)Biochim. Biophys. Acta 779, 89–137.

    PubMed  CAS  Google Scholar 

  4. Spector, A.A., and Yorek, M.D. (1985)J. Lipid Res. 26, 1015–1035.

    PubMed  CAS  Google Scholar 

  5. American Institute of Nutrition (1977)J. Nutr. 107, 1340–1348.

    Google Scholar 

  6. American Institute of Nutrition (1980)J. Nutr. 110, 1726.

    Google Scholar 

  7. Folch, J., Lees, M., and Sloane-Stanley, G.H. (1957)J. Biol. Chem. 226, 497–509.

    PubMed  CAS  Google Scholar 

  8. Stoffel, W., Chu, F., and Ahrens, E.H., Jr. (1959)Anal. Chem. 307, 307–308.

    Article  Google Scholar 

  9. Gourley, G.R., Farrell, P.M., and Odell, G.B. (1982)Am. J. Clin. Nutr. 36, 1194–1199.

    PubMed  CAS  Google Scholar 

  10. Woldegiorgis, G., Spennetta, T., Corkey, B.E., Williamson, J.R., and Shrago, E. (1985)Anal. Biochem. 150, 8–12.

    Article  PubMed  CAS  Google Scholar 

  11. Molaparast-Saless, F., Shrago, E., Spennetta, T., Donatello, S., Kneeland, L.M., Nellis, S.H., and Liedtke, A.J. (1988)Lipids 23, 490–492.

    Article  PubMed  CAS  Google Scholar 

  12. SAS Institute Inc., SAS User's Guide (1985)Statistics (Version 5 ed.) SAS Institute Inc. Cary, NC.

    Google Scholar 

  13. Steele, R.G.D., and Torrie, J.H. (1980)Principles and Procedures of Statistics (2nd ed.) pp. 173–177, McGraw-Hill, New York, NY.

    Google Scholar 

  14. Cohen, L.A., Thompson, D.O., Choi, K., Karmali, R.A., and Rose, D.P. (1986)JNCI 77, 43–51.

    PubMed  CAS  Google Scholar 

  15. Field, C.I., and Clandinin, M.T. (1984)Nutr. Res. 4, 743–755.

    Article  CAS  Google Scholar 

  16. Brenner, R.R. (1982)Prog. Lipid Res. 20, 41–47.

    Article  Google Scholar 

  17. Lasekan, J.B., and Ney, D.M. (1988)FASEB J. 2, 755.

    Google Scholar 

  18. Grinna, L.S. (1977)Mech. Ageing Dev. 6, 197–205.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Wisconsin, 537O6, Madison, WI

    Denise M. Ney, John B. Lasekan, Terry Spennetta, Mike Grahn & Earl Shrago

  2. Dept. of Nutritional Sciences, University of Wisconsin-Madison, 1415 Linden Dr., 53706, Madison, WI

    Denise M. Ney, John B. Lasekan, Terry Spennetta, Mike Grahn & Earl Shrago

Authors
  1. Denise M. Ney
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John B. Lasekan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Terry Spennetta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mike Grahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Earl Shrago
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Ney, D.M., Lasekan, J.B., Spennetta, T. et al. Effect of dietary fat on individual long-chain fatty acyl-CoA esters in rat liver and skeletal muscle. Lipids 24, 233–235 (1989). https://doi.org/10.1007/BF02535241

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02535241

Keywords

Search

Navigation