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Transformation of arachidonic acid into monohydroxy-eicosatetraenoic acids by mouse peritoneal macrophages

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Lipids

Abstract

Mouse peritoneal macrophages synthesize 6 monohydroxylated eicosatetraenoic acids when incubated with exogenous arachidonic acid. These compounds were identified by chromatographic techniques (high pressure liquid chromatography and high efficiency glass capillary column gas chromatography and mass spectrometry. The chromatographic and spectrometric data are presented. These results show that peritoneal macrophages constitute one of the best systems to study in evaluating the metabolism of oxygenated products of arachidonic acid.

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Authors and Affiliations

  1. Facultè de Mèdecine et de Pharmacie, Laboratoire de Biochimie, 2 rue du docteur Marcland-C.H.U. Dupuytren, 87031, Limoges

    Hélène Rabinovitch, Jacqueline Durand, Michel Rigaud & Jean-Christian Breton

  2. Laboratoires SOPHARGA, Tour Roussel-Nobel, cedes 3, 92080, Paris La Defense, France

    Francois Mendy

Authors
  1. Hélène Rabinovitch
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  2. Jacqueline Durand
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  3. Michel Rigaud
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  4. Francois Mendy
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  5. Jean-Christian Breton
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Rabinovitch, H., Durand, J., Rigaud, M. et al. Transformation of arachidonic acid into monohydroxy-eicosatetraenoic acids by mouse peritoneal macrophages. Lipids 16, 518–524 (1981). https://doi.org/10.1007/BF02535050

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  • DOI: https://doi.org/10.1007/BF02535050

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