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Obesity: Can some fat cells enlarge while others are shrinking?

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Lipids

Abstract

CBA mice were made obese by injection with gold thioglucose (GTG). After receiving transplants of “lean” and “GTG-obese” fat under separate kidney capsules, the host mice were fed a restricted diet for three weeks. Over this period, the fat cells in the lean grafts enlarged whereas the fat cells in the GTG-obese grafts shrank. Concurrent fat loss and fat gain can therefore take place.

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Author notes

  1. Margaret Aswell

    Present address: MRC Dunn Nutrition Unit, University of Cambridge and Medical Research Council, Dunn Nutritional Laboratory, Milton Road, CB4 1XJ, Cambridge, U.K.

  2. C. J. Meade

    Present address: Lilly Research Centre, Erl Wood Manor, GU20 6PH, Windiesham, Surrey, U.K.

Authors and Affiliations

  1. Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK

    Margaret Aswell & C. J. Meade

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  1. Margaret Aswell
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  2. C. J. Meade
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Aswell, M., Meade, C.J. Obesity: Can some fat cells enlarge while others are shrinking?. Lipids 16, 475–478 (1981). https://doi.org/10.1007/BF02535018

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  • DOI: https://doi.org/10.1007/BF02535018

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