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Effect of candicidin on cholesterol and bile acid metabolism in the rat

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Lipids

Abstract

Sterol metabolism studies were carried out in rats maintained on a diet containing a polyene antibiotic, candicidin, (30 mg/kg/day) for 2-1/2 months. Compared to the controls, the candicidintreated animals had a smaller food intake and weight gain during this period. There was no difference between the 2 groups in serum cholesterol levels, biliary cholesterol or bile acid concentrations. However, in the experimental group, liver cholesterol content decreased by 27% and hepatic HMG-CoA reductase increased by 36%. Candicidin administration produced an 84% increase in neutral sterol output without change in bile acid output. Cholesterol absorption was reduced 80% by candicidin feeding. The weight of ventral prostate was reduced 33% by candicidin administration. Prostatic HMG-CoA reductase levels were 3 times higher than those of the liver, but enzyme activity was unchanged by candicidin treatment.

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Authors and Affiliations

  1. Department of Surgery, Beth Israel Medical Center, 10003, New York, NY

    Anil K. Singhal, Erwin H. Mosbach & Carl P. Schaffner

  2. Waksman Institute of Microbiology, Rutgers-The State University of New Jersey, 08903, New Brunswick, NJ

    Anil K. Singhal, Erwin H. Mosbach & Carl P. Schaffner

Authors
  1. Anil K. Singhal
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  2. Erwin H. Mosbach
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  3. Carl P. Schaffner
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Singhal, A.K., Mosbach, E.H. & Schaffner, C.P. Effect of candicidin on cholesterol and bile acid metabolism in the rat. Lipids 16, 423–426 (1981). https://doi.org/10.1007/BF02535009

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  • DOI: https://doi.org/10.1007/BF02535009

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