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Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate

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Lipids

Abstract

Thromboxane (TXB2) and malonaldehyde (MDA) production by thrombin-stimulated washed platelet were evaluated in rats fed 6 combinations of dietary vitamin E (0, 100, 1000 ppm) and linoleate (6.5 and 17.0 en%) for 23 weeks. The molar ratio of MDA:TXB2 was consistently near 3 in all groups studied. In animals receiving the lower linoleate diets, TXB2 and MDA synthesis were inversely related to the dietary vitamin E concentrations and the levels of MDA and TXB2 were positively correlated (r=0.99) with decreasing vitamin E in the diet. High dietary linoleate (17.0 en%), independent of vitamin E status, reduces TXB2 and MDA synthesis. The importance of dietary antioxidant on platelet prostanoid synthesis is discussed.

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Author notes

  1. Alvin C. Chan (Assistant Professor)

    Present address: Department of Biochemistry, University of Ottawa, I1N 9B4, Ottawa, Ontaio, Canada

Authors and Affiliations

  1. Department of Foods and Nutrition, University of Manitoba, R3T 2N2, Winnipeg, Manitoba, Canada

    Suzanne S. -J. Hamelin & Alvin C. Chan (Assistant Professor)

Authors
  1. Suzanne S. -J. Hamelin
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  2. Alvin C. Chan
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Hamelin, S.S.J., Chan, A.C. Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate. Lipids 18, 267–269 (1983). https://doi.org/10.1007/BF02534560

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  • DOI: https://doi.org/10.1007/BF02534560

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