Abstract
A semisynthetic diet containing adequate amounts of vitamin E and 10% (w/w) of a mixture of polyunsaturated oils subjected to heating and characterized by elevated indexes of thermal alteration (polar component, dimer triglyceride, altered triglyceride contents and reduced α-tocopherol levels) was fed to growing male rats for a period of eight weeks. It resulted in a selective alteration of the production of vascular eicosanoids (elevation of platelet thromboxane formation and decrease of vascular prostacyclin release) compared to the values found in rats fed a diet containing a fresh mixture of polyunsaturated oils. Major nutritional parameters, plasma lipids and the fatty acid profiles of plasma, liver and heart lipids were not different in the two groups of animals. Supplementation of an excess vitamin E (300 mg/kg) to the diet containing heated fat neutralized the adverse effects of heated fat on vascular eicosanoid production.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kaunitz, H., Johnson, R.E., and Pegus, L. (1965) J. Am. Oil Chem. Soc. 42, 770–774.
Thompson, J.A., Paulose, M.M., Reddy, B.R., Krishnamurthy, R.G., and Chang, S.S. (1967) Food Technol. 21, 405–407.
Risser, N., Kummerow, F.A., and Perkins, E.G. (1966) Prog. Soc. Exp. Biol. Med. 121, 294–298.
Artman, N.R. (1969) in Advances in Lipid Research (Paoletti, R., and Kritchevsky, D., eds.) Vol. 7, pp. 245–330, Academic Press, New York and London.
Sahasrabudhe, M.R., and Bhalerao, R.V. (1963) J. Am. Oil Chem. Soc. 40, 711–712.
Sahasrabudhe, M.R., and Faru, I.G. (1964) J. Am. Oil Chem. Soc. 41, 264–267.
Keys, A. (1975) Atherosclerosis 22, 149–192.
Glueck, C.J. (1979) Am. J. Clin. Nutr. 32, 2637–2703.
Moncada, S., Gryglewski, R.J., Bunting, S., and Vane, J.R. (1976) Prostaglandins 12, 715–737.
Karpen, C.W., Merola, A.J., Trewyn, R.W., Cornwell, D.G., and Panganamala, R.V. (1981) Prostaglandins 22, 651–661.
Okuma, M., Takayama, H., and Uchino, H. (1980) Prostaglandins 19, 527–536.
Hamelin, S.St.J., and Chan, A.C. (1983) Lipids 18, 267–269.
Billek, G., Guhr, G., and Waibel, S. (1978) J. Am. Oil Chem. Soc. 55, 728–734.
Paradis, A.J., and Nawar, W.W. (1981) J. Am. Oil Chem. Soc. 58, 635–638.
Plattner, R.D. (1981) J. Am. Oil Chem. Soc. 58, 638–642.
Carpenter, A.P. (1979) J. Am. Oil Chem. Soc. 56, 668–671.
Folch-Pi, J., Lees, M., and Sloane-Stanley, G.H. (1957) J Biol. Chem. 226, 497–509.
Rouser, G., Kritchevsky, G., Yamamoto, A., Simon, G., Galli, C., and Bauman, A.J. (1969) in Methods in Enzymology (Lowenstein, J.M., ed.) Vol. 14, pp. 272–316, Academic Press, New York.
Granstrom, E., Kindall, H., and Samuelsson, B. (1976) Anal. Lett. 9, 611–627.
Galli, C., Petroni, A., Socini, A., Agradi, E., Colombo, C., Folco, G.C., and Tremoli, E. (1981) Prostaglandins 22, 703–713.
Socini, A., Galli, C., Colombo, C., and Tremoli, E. (1983) Prostaglandins 25, 693–710.
Salmon, J.A. (1978) Prostaglandins 15, 383–397.
Harris, P.L., and Embree, N.D. (1963) Am. J. Clin. Nutr. 13, 385–392.
Galli, C., Agradi, E., Petroni, A., and Tremoli, E. (1981) Lipids 14, 165–172.
Needleman, S.W., Spector, A.A., and Hoak, S.C. (1982) Prostaglandins 24, 607–622.
Stuart, M.J., Gerrard, J.M., and White, J.G. (1980) New Engl. J. Med. 302, 6–10.
Tremoli, E., Folco, G.C., Agradi, E., and Galli, C. (1979) Lancet 1, 107–108.
Author information
Authors and Affiliations
About this article
Cite this article
Giani, E., Masi, I. & Galli, C. Heated fat, vitamin E and vascular eicosanoids. Lipids 20, 439–448 (1985). https://doi.org/10.1007/BF02534235
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02534235