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Hypolipidemic effects in monkeys of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

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Lipids

Abstract

The fungal metabolite ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, has been shown to be significantly effective in lowering serum cholesterol levels in cynomolgus monkeys at doses of 20–50 mg/kg per day. Levels of serum phospholipids and triglycerides were, however, not significantly changed by the administration of the drug. Of the serum lipoprotein fractions, a β-lipoprotein corresponding to low density lipoprotein was preferentially reduced by the drug treatment. Fecal excretion of neutral sterols was unaffected but that of bile acids was slightly elevated by the administration of ML-236B.

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Authors and Affiliations

  1. Fermentation Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, 140, Tokyo, Japan

    Masao Kuroda, Yoshio Tsujita, Kazuhiko Tanzawa &  Akira Endo

Authors
  1. Masao Kuroda
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  2. Yoshio Tsujita
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  3. Kazuhiko Tanzawa
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  4. Akira Endo
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Kuroda, M., Tsujita, Y., Tanzawa, K. et al. Hypolipidemic effects in monkeys of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Lipids 14, 585–589 (1979). https://doi.org/10.1007/BF02533537

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  • DOI: https://doi.org/10.1007/BF02533537

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