Abstract
Human blood platelets, which previously have been shown to possess the necessary enzymic system for the synthesis of prostaglandins E, are also able to synthesize other prostaglandins, namely PGF, PGA and PGB. The synthesis and degradation rate of the prostaglandins were studied by chase experiments. Their synthesis rate was ca. 0.025 nmol acetate incorporated into PGE1 (and E2) per 109 platelets, while their degradation rate per hour was ca. 13% (PGE) and 8% (PGF) of the initial amount.
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Srivastava, K.C., Clausen, J. Synthesis of prostaglandins (PGE, PGF, PGA and PGB) in human platelets. Lipids 7, 762–765 (1972). https://doi.org/10.1007/BF02533242
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DOI: https://doi.org/10.1007/BF02533242