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Metabolism of 1-14C-methyl linoleate hydroperoxide in the rabbit

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Lipids

Abstract

The metabolism of 1-14C-methyl linoleate hydroperoxide (1-14C-MLHP) by the rabbit was investigated. Administration of 1.1–1.9 mg of 1-14C-MLHP by ear vein injection proved lethal to four of the nine experimental animals. After 2 hr the lungs and liver contained 3.3% and 7.2%, respectively, of the dose. This radioactivity was found to be associated primarily with intact 1-14C-MLHP. The triglycerides from these tissues also contained14C-trienoic and14C-dienoic fatty acids. Of the dose, 68% was recovered as14CO2 in 2 hr compared to 39% after 1-14C-methyl linoleate injection. The triglycerides from kidney adipose tissue contained a small amount of14C-hydroxy fatty acid, providing confirmation of previous evidence for the presence of a fatty acid hydroperoxide reductase in animal tissues.

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Authors and Affiliations

  1. Department of Food Science, University of Illinois at Urbana-Champaign, 61801, Illinois

    G. M. Findlay, H. H. Draper & J. G. Bergan

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  1. G. M. Findlay
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  2. H. H. Draper
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  3. J. G. Bergan
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Findlay, G.M., Draper, H.H. & Bergan, J.G. Metabolism of 1-14C-methyl linoleate hydroperoxide in the rabbit. Lipids 5, 970–975 (1970). https://doi.org/10.1007/BF02533199

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  • DOI: https://doi.org/10.1007/BF02533199

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