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Effect of androgens on serum lipids and lipoproteins

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Lipids

Abstract

The effects of androgens on lipid transport and metabolism have been reviewed. These effects are probably independent of the androgenic and anabolic activities of the androgens, although the molecular mechanism of action is still not known. Presumably the lowering by androgens of the concentrations of serum lipids and lipoproteins could be the consequence possibly of a primary, inhibitory effect on the synthesis of apolipoprotein A. In addition the role of increased lipolytic activities in plasma and of effects on intermediatry metabolism has been considered.

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References

  1. Wilson, J.D., N. Bruchovsky and J.N. Chatfield, in “Progress in Endocrinology,” Excerpta Medica Found,” Amsterdam, 1969, p. 17.

    Google Scholar 

  2. Eberlein, W.R., J. Winter and R.L. Rosenfield, in “Hormones in Blood”, Vol. 2., Edited by C.H. Gray and A.L. Bacharach, Academic Press, New York, 1967, p. 187.

    Google Scholar 

  3. Mausvais-Jarvis, P., H.H. Floch and J. Bercovici, J. Clin. Endocr. 28:460 (1968).

    Google Scholar 

  4. Applezweig, N., “Steroid Drugs,” McGraw-Hill Co., New York, 1962, p. 93.

    Google Scholar 

  5. Kochakian, C.D., and C.E. Stettner, Am. J. Physiol. 155:255 (1948).

    CAS  PubMed  Google Scholar 

  6. Korner, A., and F.G. Young, J. Endocrinol. 13:78 (1955).

    PubMed  CAS  Google Scholar 

  7. Laron, A., and A. Kowadlo-Silbergeld, Acta Endocrinol. 45:427 (1964).

    PubMed  CAS  Google Scholar 

  8. Laron, Z., and A. Kowadlo-Silbergeld, Israel J. Med. Sci. 1:91 (1965).

    PubMed  CAS  Google Scholar 

  9. Glueck, C.J., D. Scheel, J. Fishback and P. Steiner JAOCS 49:110 (1972).

    Google Scholar 

  10. Furman, R.H., P. Alaupovic, R.H. Bradford and R.P. Howard, Progr. Biochem. Pharmacol. 4:334 (1968).

    CAS  Google Scholar 

  11. Hatch, F.T., and R.S. Lees, Advan. Lipid Res. 6:1 (1968).

    CAS  Google Scholar 

  12. Furman, R.H., P. Alaupovic and R.P. Howard, Progr. Biochem. Pharmacol. 2:215 (1967).

    CAS  Google Scholar 

  13. Russ, E.M., H.A. Eder and D.P. Barr, Am. J. Med. 19:4 (1955).

    Article  PubMed  CAS  Google Scholar 

  14. Berezin, D., and W. von Studnitz, Acta Endocrinol. 25:435 (1957).

    PubMed  CAS  Google Scholar 

  15. Furman, R.H., L.N. Norcia, C.W. Robinson, Jr., and I.E. Gonzales, Am. J. Physiol. 191:561 (1957).

    PubMed  CAS  Google Scholar 

  16. Pick, R., J. Stamler, S. Rodbard and L.N. Katz, Circulation Res. 7:202 (1959).

    PubMed  CAS  Google Scholar 

  17. Fillios, L.C., Endrocrinology 60:22 (1957).

    CAS  Google Scholar 

  18. Oliver, M.F., and G.S. Boyd, Lancet 2:1273 (1956).

    Article  Google Scholar 

  19. Furman, R.H., and R.P. Howard, Ann. Internal Med. 47:969 (1957).

    CAS  Google Scholar 

  20. Abell, L.L., E.H. Mosbach and F.E. Kendall, Circulation Res. 10:846 (1962).

    PubMed  CAS  Google Scholar 

  21. Furman, R.H., C.W. Robinson, Jr., R.H. Bradford, P. Alaupovic and L.N. Norcia, Proc. Soc. Exp. Biol. (N.Y.) 113:789 (1963).

    CAS  Google Scholar 

  22. Solyom, A., R.H. Bradford and R.H. Furman Biochim. Biophys. Acta 236:563 (1971).

    PubMed  CAS  Google Scholar 

  23. Abell, L.L., and E.H. Mosbach, J. Lipid Res. 3:88 (1962).

    CAS  Google Scholar 

  24. Hellman, L., H.L. Bradlow, B. Zumoff, D.K. Fukushima and T.F. Gallagher, J. Clin. Endocr. Metab. 19:936 (1959).

    Article  PubMed  CAS  Google Scholar 

  25. Furman, R.H., and R.P. Howard, Metabolism 11:76 (1962).

    PubMed  CAS  Google Scholar 

  26. Furman, R.H., R.P. Howard, L.N. Norcia and E.C. Keaty, Am. J. Med. 24:80 (1958).

    Article  PubMed  CAS  Google Scholar 

  27. Howard, R.P., and Furman, R.H., Ann. Internal Med. 56:688 (1962).

    Google Scholar 

  28. Abell, L.L., and E.H. Mosbach, J. Lipid Res. 9:98 (1968).

    PubMed  CAS  Google Scholar 

  29. Gofman, J.W., L. Robin, J.P. McGinley and H.B. Jones, Am. J. Med. 17:514 (1954).

    Article  PubMed  CAS  Google Scholar 

  30. Jones, R.J., L. Cohen and H. Corbus, Ibid. 19:71 (1955).

    Article  PubMed  CAS  Google Scholar 

  31. Furman, R.H., R.P. Howard, K. Lakshmi and L.N. Norcia, Am. J. Clin. Nutr. 9:73 (1961).

    PubMed  CAS  Google Scholar 

  32. Cornwell, D.G., F.A. Kruger, G.J. Hamwi and J.B. Brown, Ibid. 9:24 (1961).

    PubMed  CAS  Google Scholar 

  33. Miller, H., J.A. Durant, J.M. Cowan, J.M.S. Knott and E.S. Garnett, J. Endocr. 48:55 (1970).

    PubMed  CAS  Google Scholar 

  34. Wilson, H., and S. Schenker, Acta Endocrinol. 46:197 (1964).

    PubMed  CAS  Google Scholar 

  35. Adlercreutz, H., J. Kerstell, A. Svanborg and R. Vihko, Ann. Med. Esp. Fenn. 46:165 (1968).

    CAS  Google Scholar 

  36. Rao, L.G.S., Lancet 2:390 (1970).

    Article  PubMed  CAS  Google Scholar 

  37. Southren, A.L., and G.G. Gordon, Mount Sinai J. Med. (N.Y.) 37:516 (1970).

    CAS  Google Scholar 

  38. Sonka, J., I. Gragorova, J. Pav and F. Skrha, Lancet 2:44 (1964).

    PubMed  CAS  Google Scholar 

  39. Marks, P.A., and J. Banks, Proc. Natl. Acad. Sci. 46:447 (1960).

    Article  PubMed  CAS  Google Scholar 

  40. Felt, V., and L. Starka, Cor et vasa 8: 40 (1966).

    PubMed  CAS  Google Scholar 

  41. Ben-David, M., S. Dikstein, G. Bismuth and F.G. Sulman, Proc. Soc. Exp. Biol. (N.Y.) 125:1136 (1967).

    CAS  Google Scholar 

  42. Nakamura, K., Y. Masuda and H. Nakamura, J. Atherosclerosis Res. 7:253 (1967).

    Article  CAS  Google Scholar 

  43. Nakamura, K., H. Nakamura, Y. Masuda and Y. O’Saki, Naunyn-Schmiedebergs: Arch. Pharmack. 264:327 (1969).

    CAS  Google Scholar 

  44. Solyom, A., R.H. Bradford and R.H. Furman, Biochim. Biophys. Acta 229:471 (1971).

    PubMed  CAS  Google Scholar 

  45. Solyom, A., R.H. Bradford and R.H. Furman, Am. J. Physiol. 221:1587 (1971).

    PubMed  CAS  Google Scholar 

  46. Oberdorfer, A., Acta Endocrinol. 64(Suppl.):143 (1970).

    Google Scholar 

  47. Ingbar, S.H., in “Progress in Endocrinology”, Excerpta Medica Found., Amsterdam, 1969, p. 1200.

    Google Scholar 

  48. Federman, D.D., J. Robbins and J.E. Rall, J. Clin. Invest. 37:1024 (1958).

    Article  PubMed  CAS  Google Scholar 

  49. Havel, R.J., V.G. Shore, B. Shore and D.M. Bier, Circulation Res. 27:595 (1970).

    PubMed  CAS  Google Scholar 

  50. LaRosa, J.C., R.I. Levy, P. Herbert, S.E. Lux and D.S. Fredrickson, Biochem. Biophys. Res. Commun. 41:57 (1970).

    Article  PubMed  CAS  Google Scholar 

  51. Ganesan, D., R.H. Bradrod, P. Alaupovic and W.J. McConathy, Fed. Proc. 30:208 (1971).

    Google Scholar 

  52. Ritter, M.C., and M.E. Dempsey, J. Biol. Chem. 246:1536 (1971).

    PubMed  CAS  Google Scholar 

  53. Scallen, T.J., M.W. Schuster, A.K. Dhar and H.B. Skrdlant, Lipids 6:162 (1970).

    Article  Google Scholar 

  54. Trams, E.G., and E.A. Brown, J. Theoret. Biol. 12:311 (1966).

    Article  CAS  Google Scholar 

  55. Farber, E., and A. Segaloff, J. Biol. Chem. 216:471 (1955).

    PubMed  CAS  Google Scholar 

  56. Windmueller, H.G., and R.I. Levy, Ibid. 242:2246 (1967).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, 20014, Bethesda, Maryland

    Antal Solyom

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  1. Antal Solyom
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Special Fellowship Awardee (1F11 NSO2245-01) from the National Institute of Neurological Diseases and Stroke

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Solyom, A. Effect of androgens on serum lipids and lipoproteins. Lipids 7, 100–105 (1972). https://doi.org/10.1007/BF02532595

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  • DOI: https://doi.org/10.1007/BF02532595

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