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Structure determinations and synthesis of pharmacologically active phospholipids from kidney and intestine

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Lipids

Abstract

The chemical structures of an acidic phospholipid originally isolated from equine intestine by Vogt and of a phospholipid isolated from rabbit kidney medulla by Walaszek are shown by total synthesis to be similar mixtures of 2-alkyl (and alkenyl)-4-hydroxymethyl-1,3-dioxolane-dihydrogen phosphate esters. In these materials, the alkyl residues derive primarily from oleyl, palmityl and linoleyl aldehydes. The smooth muscle contracting activity observed in the natural substances is shown to reside exclusively in the oleyl aldehyde derivative.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, The University of Kansas, 66044, Lawrence, Kansas

    R. A. Wiley & D. D. Sumner

  2. Department of Pharmacology, The University of Kansas Medical Center, Kansas City, Kansas

    Edward J. Walaszek

Authors
  1. R. A. Wiley
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  2. D. D. Sumner
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  3. Edward J. Walaszek
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Wiley, R.A., Sumner, D.D. & Walaszek, E.J. Structure determinations and synthesis of pharmacologically active phospholipids from kidney and intestine. Lipids 5, 803–811 (1970). https://doi.org/10.1007/BF02531972

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  • DOI: https://doi.org/10.1007/BF02531972

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