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Comparative effect of a protein diet on the desaturation, elongation and simultaneous desaturation and elongation of linoleic acid

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Lipids

Abstract

The effect of a protein diet on the biosynthesis of polyunsaturated fatty acids of the linoleic acid family was studied by incubation of rat liver microsomes with labeled linoleic acid. The incubation was performed in desaturating, elongating and desaturating-elongating conditions. In desaturating conditions, linoleic acid was converted to γ-linolenic acid, whereas in elongating conditions it was converted to 20∶2, 22∶2 and 24∶2. In desaturating-elongating conditions, labeling was found in γ 18∶3, 20∶2, 20∶3, 20∶4 and 22∶2. A protein diet increased the oxidative desaturation of linoleic acid to γ-linolenic and arachidonic acid biosynthesis, whereas the elongating reaction was not enhanced in the experimental conditions tested. It is suggested that the main controllable step in the linoleic acid family is the oxidative desaturation of linoleic acid to γ-linolenic acid.

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Author notes

  1. R. O. Peluffo (Member) & R. R. Brenner (Member)

    Present address: Carrera del Investigador Científico of the Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina

Authors and Affiliations

  1. Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Calle 60 y 120, La Plata, Argentina

    I. N. T. De Gómez Dumm, R. O. Peluffo (Member) & R. R. Brenner (Member)

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  1. I. N. T. De Gómez Dumm
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  2. R. O. Peluffo
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  3. R. R. Brenner
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De Gómez Dumm, I.N.T., Peluffo, R.O. & Brenner, R.R. Comparative effect of a protein diet on the desaturation, elongation and simultaneous desaturation and elongation of linoleic acid. Lipids 7, 590–592 (1972). https://doi.org/10.1007/BF02531960

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  • DOI: https://doi.org/10.1007/BF02531960

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