Skip to main content
SpringerLink
Log in

Elevated soluble CD23 levels in the sera from patients with localized scleroderma

  • Original Paper
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Soluble CD23 (sCD23) is closely related to B-cell activation and elevated serum levels of sCD23 have been reported in several autoimmune disorders. This study investigated the serum levels of sCD23 and determined the correlation of sCD23 with other immunologic abnormalities and clinical features in localized scleroderma. We examined 49 serum samples by an enzyme-linked immunosorbent assay in the following three subgroups: 15 patients with generalized morphoea, 22 with linear scleroderma, and 12 with morphoea. The serum levels of sCD23 were significantly elevated in patients with localized scleroderma, compared with those in healthy individuals. Of the three subgroups of localized scleroderma, patients with generalized morphoea had the highest levels of serum sCD23. The frequency of IgM antihistone antibody (AHA) and IgM rheumatoid factor (RF), the number of linear lesions, and the frequency of muscle involvement were significantly higher in patients with elevated sCD23 levels than in those with normal levels of sCD23. A significant correlation between the serum sCD23 level and the number of involved areas of the body was observed. Our data suggest that the activation of virgin B cells, which is reflected by elevated sCD23 levels, is closely associated with the production of IgM autoantibodies in localized scleroderma and furthermore that the serum levels of sCD23 are a new serological indicator of the severity of localized scleroderma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Takehara K, Moroi Y, Nakabayashi Y, Ishibashi Y (1983) Antinuclear antibodies in localized scleroderma. Arthritis Rheum 26:612–616

    PubMed  CAS  Google Scholar 

  2. Ruffatti A, Peserico A, Glorioso S, Fiocco U, Rossi L, Gambari P, Todesco S (1986) Anticentromere antibody in localized scleroderma. J Am Acad Dermatol 15:637–642

    PubMed  CAS  Google Scholar 

  3. Falanga V, Medsger TA Jr, Reichlin M, Rodnan GP (1986) Linear scleroderma: clinical spectrum, prognosis, and laboratory abnormalities. Ann Intern Med 104:849–857

    PubMed  CAS  Google Scholar 

  4. Falanga V, Medsger TA Jr, Reichlin M (1987) Antinuclear and anti-single-stranded DNA antibodies in morphea and generalized morphea. Arch Dermatol 123:350–353

    Article  PubMed  CAS  Google Scholar 

  5. Kikuchi K, Takehara K, Ishibashi Y (1989) Antinuclear antibodies in localized sleroderma: unique staining in chromosome spreads. J Am Acad Dermatol 21:1301–1303

    Article  PubMed  CAS  Google Scholar 

  6. Sato S, Ihn H, Soma Y, Igarashi A, Tamaki T, Kikuchi K, Ishibashi Y, Takehara K (1993) Antihistone antibodies in patients with localized scleroderma. Arthritis Rheum 36:1137–1141

    PubMed  CAS  Google Scholar 

  7. Scarola JA, Shulman LE (1975) Serologic abnormalities and their significance in localized scleroderma. Arthritis Rheum 18: 52

    Google Scholar 

  8. Falanga V, Medsger TA Jr, Reichlin M (1985) High titers of antibodies to single-stranded DNA in linear scleroderma. Arch Dermatol 121:345–347

    Article  PubMed  CAS  Google Scholar 

  9. Takehara K, Kikuchi K, Soma Y, Igarashi A, Ishibashi Y (1990) Anti-single-stranded DNA antibody and muscle involvement in localized scleroderma. Arch Dermatol 126:1368–1369

    Article  PubMed  CAS  Google Scholar 

  10. Sato S, Fujimoto M, Ihn H, Kikuchi K, Takehara K (1994) Antigen specificity of antihistone antibodies in localized scleroderma. Arch Dermatol 130:1273–1277

    Article  PubMed  CAS  Google Scholar 

  11. Ihn H, Sato S, Fujimoto M, Kikuchi K, Takehara K (1995) Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma. Arch Dermatol Res 287:193–197

    Article  PubMed  CAS  Google Scholar 

  12. Delespesse G, Suter U, Mossalayi D, Bettler B, Sarfati M, Hofstetter H, Kilcherr E, Debre P, Dalloul A (1991) Expression, structure, and function of the CD23 antigen. Adv Immunol 49: 149–191

    Article  PubMed  CAS  Google Scholar 

  13. Yukawa K, Kikutani H, Owaki H, Yamasaki K, Yokota A, Nakamura H, Barsumian EL, Hardy RR, Suemura M, Kishimoto T (1987) A B cell-specific differentiation antigen, CD23, is a receptor for IgE (FcεR) on lymphocytes. J Immunol 138:2576–2580

    PubMed  CAS  Google Scholar 

  14. Kikutani H, Suemura M, Owaki H, Nakamura H, Sato R, Yamasaki K, Barsumian EL, Hardy RR, Kishimoto T (1986) Fcε receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. J Exp Med 164:1455–1469

    Article  PubMed  CAS  Google Scholar 

  15. Sarfati M, Nutman T, Fonteyn C, Delespesse G (1986) Presence of antigenic determinants common to Fc IgE receptors on human macrophages, T and B lymphocytes and IgE-binding factors. Immunology 59:569–575

    PubMed  CAS  Google Scholar 

  16. Joseph M, Capron A, Ameisen JC, Capron M, Vorng H, Pancre V, Kusnierz JP, Auriault C (1986) The receptor for IgE on blood platelets. Eur J Immunol 16:306–312

    PubMed  CAS  Google Scholar 

  17. Capron M, Capron A, Dessaint JP, Torpier G, Johansson SGO, Prin L (1981) Fc receptors for IgE on human and rat eosinophils. J Immunol 126:2087–2092

    PubMed  CAS  Google Scholar 

  18. Letellier M, Nakajima T, Pulido-Cejudo G, Hofstetter H, Delespesse G (1990) Mechanism of formation of human IgE-binding factors (soluble CD23). III. Evidence for a receptor (FcεRII)-associated proteolytic activity. J Exp Med 172:693–700

    Article  PubMed  CAS  Google Scholar 

  19. Delespesse G, Sarfati M, Hofstetter H (1989) Human IgE binding factors. Immunol Today 10:159–164

    Article  PubMed  CAS  Google Scholar 

  20. Gordon J, Flores-Romo L, Cairns JA, Millsum MJ, Lane PJ, Johnson GD, MacLennan ICM (1989) CD23: a multi-functional receptor/lymphokine? Immunol Today 10:153–157

    Article  PubMed  CAS  Google Scholar 

  21. Armitage RJ, Goff LK, Beverley PCL (1989) Expression and functional role of CD23 on T cells. Eur J Immunol 19:31–35

    PubMed  CAS  Google Scholar 

  22. Flores-Romo L, Cairns JA, Millsum MJ, Gordon J (1989) Soluble fragments of the low-affinity IgE receptor (CD23) inhibit the spontaneous migration of U937 monocytic cells: neutralization of MIF-activity by a CD23 antibody. Immunology 67: 547–549

    PubMed  CAS  Google Scholar 

  23. Sarfati M, Delespesse G (1988) Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE. J Immunol 141:2195–2199

    PubMed  CAS  Google Scholar 

  24. Mossalayi MD, Lecron JC, Dalloul AH, Sarfati M, Bertho JM, Hofstetter H, Delespesse G, Debre P (1990) Soluble CD23 (FcεRII) and interleukin 1 synergistically induce early human thymocyte maturation. J Exp Med 171:959–964

    Article  PubMed  CAS  Google Scholar 

  25. Liu Y-J, Mason DY, Johnson GD, Abbot S, Gregory CD, Hardie DL, Gordon J, MacLennan ICM (1991) Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur J Immunol 21:1905–1910

    PubMed  CAS  Google Scholar 

  26. Sato S, Fujimoto M, Ihn H, Kikuchi K, Takehara K (1994) Clinical characteristics associated with antihistone antibodies in patients with localized slceroderma. J Am Acad Dermatol 31: 567–571

    PubMed  CAS  Google Scholar 

  27. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee (1983) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 26:612–616

    Google Scholar 

  28. LeRoy EC, Black C, Fleischmajer P, et al (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 15:202–205

    PubMed  CAS  Google Scholar 

  29. Chomarat P, Briolay J, Banchereau J, Miossec P (1993) Increased production of soluble CD23 in rheumatoid arthritis, and its regulation by interleukin-4. Arthritis Rheum 36:234–242

    PubMed  CAS  Google Scholar 

  30. Gordon J (1991) CD23: novel disease marker with a split personality. Clin Exp Immunol 86:356–359

    Article  PubMed  CAS  Google Scholar 

  31. Becker H, Potyka P, Weber C, Federlin K (1991) Detection of circulatig FcεR2/CD23+ monocytes in patients with rheumatic diseases. Clin Exp Immunol 85:61–65

    Article  PubMed  CAS  Google Scholar 

  32. Bansal A, Roberts T, Hay EM, Kay R, Pumphrey RSH, Wilson PB (1992) Soluble CD23 levels are elevated in the serum of patients with primary Sjögren's syndrome and systemic lupus erythematosus. Clin Exp Immunol 89:452–455

    Article  PubMed  CAS  Google Scholar 

  33. Matsumoto T, Miike T, Yamaguchi K, Murakami M, Kawabe T, Yodoji J (1991) Seru levels of soluble IL-2 receptor, IL-4 and IgE-binding factors in childhood allergic diseases. Clin Exp Immunol 85:288–292

    Article  PubMed  CAS  Google Scholar 

  34. Yanagihara Y, Sarfati M, Marsh D, Nutman T, Delespesse G (1990) Serum levels of IgE-binding factor (soluble CD23) in diseases associated with elevated IgE. Clin Exp Allergy 20: 395–401

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Shinichi Sato, Manabu Fujimoto, Kanako Kikuchi, Hironobu Ihn & Kunihiko Tamaki

  2. Department of Dermatology, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920, Ishikawa, Japan

    Kazuhiko Takehara

Authors
  1. Shinichi Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manabu Fujimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kanako Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hironobu Ihn
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kunihiko Tamaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kazuhiko Takehara
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sato, S., Fujimoto, M., Kikuchi, K. et al. Elevated soluble CD23 levels in the sera from patients with localized scleroderma. Arch Dermatol Res 288, 74–78 (1996). https://doi.org/10.1007/BF02505047

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02505047

Key words

Search

Navigation