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Model of amino acid substitution in proteins encoded by mitochondrial DNA

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Abstract

Mitochondrial DNA (mtDNA) sequences are widely used for inferring the phylogenetic relationships among species. Clearly, the assumed model of nucleotide or amino acid substitution used should be as realistic as possible. Dependence among neighboring nucleotides in a codon complicates modeling of nucleotide substitutions in protein-encoding genes. It seems preferable to model amino acid substitution rather than nucleotide substitution. Therefore, we present a transition probability matrix of the general reversible Markov model of amino acid substitution for mtDNA-encoded proteins. The matrix is estimated by the maximum likelihood (ML) method from the complete sequence data of mtDNA from 20 vertebrate species. This matrix represents the substitution pattern of the mtDNA-encoded proteins and shows some differences from the matrix estimated from the nuclear-encoded proteins. The use of this matrix would be recommended in inferring trees from mtDNA-encoded protein sequences by the ML method.

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Authors and Affiliations

  1. Department of Statistical Science, The Graduate University for Advanced Studies, 4-6-7 Minami-Azabu, Minato-Ku, 106, Tokyo, Japan

    Jun Adachi

  2. The Institute of Statistical Mathematics, 4-6-7 Minami-Azabu, Minato-ku, 106, Tokyo, Japan

    Masami Hasegawa

Authors
  1. Jun Adachi
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  2. Masami Hasegawa
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Adachi, J., Hasegawa, M. Model of amino acid substitution in proteins encoded by mitochondrial DNA. J Mol Evol 42, 459–468 (1996). https://doi.org/10.1007/BF02498640

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  • DOI: https://doi.org/10.1007/BF02498640

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