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Enantioresolution of dihydropyridine substituted acid by supercritical fluid chromatography on hypercarb® with Z-(L)-arginine as chiral counter ion

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Summary

A chromatographic method is described for separation of substituted dihydropyridines on Hypercarb, porous-graphitic carbon as support and methanol-modified carbon dioxide containing Tween 60® deactivation additive, as mobile phase.

Enantiomers of a dihydropyridine substituted acid were resolved after addition of Z-(L)-arginine as ion-pairing counter ion. A 0.2 mM concentration was sufficient to achieve a resolution factor>2 or baseline resolution. The system was used to estimate the minor enantiomer below 0.1% level.

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Authors and Affiliations

  1. Department of Analytical Chemistry, AstraZeneca R&D Mölndal, 43183, Mölndal, Sweden

    O. Gyllenhaal & A. Karlsson

Authors
  1. O. Gyllenhaal
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  2. A. Karlsson
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Gyllenhaal, O., Karlsson, A. Enantioresolution of dihydropyridine substituted acid by supercritical fluid chromatography on hypercarb® with Z-(L)-arginine as chiral counter ion. Chromatographia 52, 351–355 (2000). https://doi.org/10.1007/BF02491030

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  • DOI: https://doi.org/10.1007/BF02491030

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